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Duplication of a portion of human chromosome 20q containing Topoisomerase (Top1)and Snail genes provides evidence on genome expansion and the radiation of teleost fish

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Aquatic Genomics

Summary

Zebrafish has two duplicate copies of many genes present in single copy in the human genome. Most gene duplicates map in duplicate chromosome segments, suggesting that they are the remnants of a whole genome duplication event. When did this event occur? To address this question, we mapped zebrafish orthologues of genes on human chromosome 20 (Hsa20). The results showed that LG11 and LG23 contain many orthologues of Hsa20 loci, including duplicates of SNAIL, TOPOISOMERASE-1, and KRML. Phylogenetic analysis showed that these chromosome segments were duplicated before the divergence of Cypriniform and Tetraodontiform fishes, as would be predicted by the hypothesis that a genome duplication event happened before the teleost radiation. Because differential loss of gene duplicates can facilitate reproductive isolation, and because gene duplication can foster the evolution of developmental innovations, we suggest the hypothesis that genome duplication in ray fin fish facilitated the teleost radiation, an explosion of diversity that produced half of all vertebrate species.

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Authors and Affiliations

  1. Institute of Neuroscience, University of Oregon, Eugene, OR, 97403-1254, USA

    John H. Postlethwait, Angel Amores & Yi-Lin Yan

  2. School of Biochemistry and Genetics, The Medical School, University of Newcastle, Newcastle-upon-Tyne, UK

    Carolyn Austin

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  1. John H. Postlethwait
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  2. Angel Amores
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  3. Yi-Lin Yan
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  4. Carolyn Austin
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Editors and Affiliations

  1. Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Japan

    Nobuyoshi Shimizu Ph.D. (Professor and Head) (Professor and Head)

  2. Laboratory of Genetics and Biochemistry, Graduate School of Fisheries Science, Tokyo University of Fisheries, 4-5-7 Konan, 108-8477, Minato-ku, Tokyo, Japan

    Takashi Aoki Ph.D. (Professor) & Ikuo Hirono Ph.D. (Associate Professor) (Professor) &  (Associate Professor)

  3. Tokyo University of Fisheries, 4-5-7 Konan, 108-8477, Minato-ku, Tokyo, Japan

    Fumio Takashima Ph.D. (President) (President)

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Postlethwait, J.H., Amores, A., Yan, YL., Austin, C. (2003). Duplication of a portion of human chromosome 20q containing Topoisomerase (Top1)and Snail genes provides evidence on genome expansion and the radiation of teleost fish. In: Shimizu, N., Aoki, T., Hirono, I., Takashima, F. (eds) Aquatic Genomics. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65938-9_2

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  • DOI: https://doi.org/10.1007/978-4-431-65938-9_2

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65940-2

  • Online ISBN: 978-4-431-65938-9

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