Abstract
The fact that hypothermic circulatory arrest (HCA) may result in suboptimal cerebral protection during cardio-aortic surgery, especially if HCA is prolonged, has recently been increasingly acknowledged. We have explored the physiology of hypothermia to find ways to enhance its effectiveness, including use of retrograde cerebral perfusion (RCP). RCP has additional appeal for its potential utility in reducing embolic cerebral injury. We have carried out a series of investigations of hypothermic RCP in a chronic porcine model, monitoring metabolic, electrophysiological and behavioral recovery as well as histopathology.
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© 2001 Springer Japan
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Griepp, E.B. (2001). Physiology of Hypothermic Circulatory Arrest and Retrograde Cerebral Perfusion. In: Kawada, S., Ueda, T., Shimizu, H. (eds) Cardio-aortic and Aortic Surgery. Keio University International Symposia for Life Sciences and Medicine, vol 7. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65934-1_8
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DOI: https://doi.org/10.1007/978-4-431-65934-1_8
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-65936-5
Online ISBN: 978-4-431-65934-1
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