Synthesis of α,β-Unsaturated Carboxylic Acids by Electrochemical Carboxylation of Vinyl Bromides and Its Application to the Synthesis of Anti-Inflammatory Agents

  • Masao Tokuda
  • Hisato Kamekawa
  • Hisanori Senboku


Electrochemical carboxylation of various vinyl bromides under an atmospheric pressure of carbon dioxide with a Pt cathode and an Mg anode gave the corresponding α,ß-unsaturated carboxylic acids in high yields. In the case of alkyl-substituted vinyl bromides, efficient electrochemical carboxylation was achieved by the addition of 20 mol% of NiBr2•bpy. These facile carboxylations were successfully applied to a synthesis of the precursors of nonsteroidal anti-inflammatory agents.


Unsaturated Acid Aryl Bromide Platinum Cathode Unsaturated Carboxylic Acid Magnesium Anode 
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Copyright information

© Springer Japan 1998

Authors and Affiliations

  • Masao Tokuda
    • 1
  • Hisato Kamekawa
    • 1
  • Hisanori Senboku
    • 1
  1. 1.Division of Molecular Chemistry, Graduate School of EngineeringHokkaido UniversitySapporo 060Japan

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