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Electroorganic Synthesis of Optically Active Alcohols from Ketone and Aldehyde Derivatives Using Alcohol Dehydrogenase as an Electrocatalyst

  • Susumu Kuwabata
  • Ruo Yuan
  • Shozo Watanabe
  • Hiroshi Yoneyama
Conference paper

Abstract

Asymmetric electroreduction of ketone and aldehyde derivatives was examined for two electrochemical reduction systems using alcohol dehydrogenase (ADH as an electrocatalyst. The reaction system (A) allowed asymmetric reduction of acetophenone, propiophenone, phenoxy-2-propanone, pyruvic acid and 2-phenylpropionaldehyde to corresponding optically active alcohols with the enantiomer excesses (ee) close to 100% and the current efficiencies larger than 92%, and the reaction system (B) gave 100% ee for the reduction of propiophenone, phenoxy-2-propanone, and pyruvic acid.

Keywords

Alcohol Dehydrogenase Current Efficiency Electrochemical Reduction Pyruvic Acid Enantiomer Excess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1998

Authors and Affiliations

  • Susumu Kuwabata
    • 1
  • Ruo Yuan
    • 1
  • Shozo Watanabe
    • 1
  • Hiroshi Yoneyama
    • 1
  1. 1.Department of Applied Chemistry, Faculty of EngineeringOsaka UniversitySuita, Osaka 565Japan

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