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Exploring Co-Mediated Organic Reactions. Modelling Molecular Recognition in Vitamin B12 Dependent Reactions

  • T. Darbre
  • V. Siljegovic
  • A. Amolins
  • T. Otten
  • R. Keese
  • L. Abrantes
  • J. P. Correia
Conference paper

Abstract

An in vitro catalytic cycle under electro-photochemical control has been set up for the coenzyme B12 dependent methylmalonyl-succinyl rearrangement. For molecular recognition side chains for hydrophobic interactions and A-T-base pairing have been introduced into the vitamin B12 derived catalyst and the corresponding substrates. Increased rearrangement has been observed in the hydrophobic model. Conservation of chirality in this catalytic reaction is low. According to CV the Co(II) — Co(I) reversible reduction of a thymine bearing corrin is low in acetonitrile, but complete in methanol. Anodic electropolymerisation has been observed with a pyrrol bearing corrin.

Keywords

Reductive Cleavage Redox Catalysis Transition Metal Center Corrin Ring Active Transition Metal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1).
    Y. Murakami, Y. Hisaeda, T. Olmo, J. chem Soc., Perkin 2, 1991, 405.Google Scholar
  2. 2).
    Y. Hisaeda, J. Takenaka, Y. Murakami, Electrochimica Acta, 1997, 42, 2165.CrossRefGoogle Scholar
  3. 3)a).
    T. Darbre, A. Wolleb, R. Keese, V. Šiljegovic, Heiv. Chim. Acta,1996, 79,2100;CrossRefGoogle Scholar
  4. b).
    T. Darbre, R. Keese, V. Šiljegovic, J. Chem. Soc. Chem. Commun., 1996, 561.Google Scholar
  5. 4).
    P. Bonhôte, R. Scheffold, Heiv. Chim. Acta, 1994, 74, 1425.CrossRefGoogle Scholar

Copyright information

© Springer Japan 1998

Authors and Affiliations

  • T. Darbre
    • 1
    • 2
  • V. Siljegovic
    • 1
    • 2
  • A. Amolins
    • 1
    • 2
  • T. Otten
    • 1
    • 2
  • R. Keese
    • 1
    • 2
  • L. Abrantes
    • 1
    • 2
  • J. P. Correia
    • 1
    • 2
  1. 1.Dept. of Chemistry and BiochemistryUniversity of BernBernSwitzerland
  2. 2.Faculty of SciencesUniversity of LisboaLisboaPortugal

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