Exploring Co-Mediated Organic Reactions. Modelling Molecular Recognition in Vitamin B12 Dependent Reactions
An in vitro catalytic cycle under electro-photochemical control has been set up for the coenzyme B12 dependent methylmalonyl-succinyl rearrangement. For molecular recognition side chains for hydrophobic interactions and A-T-base pairing have been introduced into the vitamin B12 derived catalyst and the corresponding substrates. Increased rearrangement has been observed in the hydrophobic model. Conservation of chirality in this catalytic reaction is low. According to CV the Co(II) — Co(I) reversible reduction of a thymine bearing corrin is low in acetonitrile, but complete in methanol. Anodic electropolymerisation has been observed with a pyrrol bearing corrin.
KeywordsReductive Cleavage Redox Catalysis Transition Metal Center Corrin Ring Active Transition Metal
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