Genetic Alterations in the Precursors of Gastric Cancer

  • Atsushi Ochiai
  • Setsuo Hirohashi


The presence of multiple genetic alterations has been established in human cancers. The evolution of sequential histological changes from normal cells through invasive cancer provides the opportunity to elucidate the molecular basis of this progression. The paradigm for such studies involves the identification of molecular genetic events that occur during the evolution of various human carcinomas, including gastric cancer. Several studies have demonstrated that multiple genetic alterations, comprising oncogene and tumor-suppressor gene mutations and loss of heterozygosity, play roles in cancer development and progression. Two histological forms of gastric carcinoma (intestinal and diffuse) and their different histogenetic and etiological backgrounds suggest that different spectra of genetic changes are involved in different tumor types. That same genetic alterations, including oncogenes and tumorsuppressor genes, have been detected in the precursors of both intestinal- and diffuse-type gastric cancers, but no specific genetic alterations have been detected in the latter. The genetic alterations in precursor lesions of gastric cancer and chronic atrophic gastritis, a precancerous condition, are summarized here. Also presented are the results of investigations into p.53 tumor-suppressor gene mutations in nonneoplastic gastric mucosa exhibiting chronic atrophic gastritis with intestinal metaplasia, an early genetic change.


Gastric Cancer Gastric Carcinoma Intestinal Metaplasia Precancerous Lesion Chronic Atrophic Gastritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Atsushi Ochiai
    • 1
  • Setsuo Hirohashi
    • 1
  1. 1.Pathology DivisionNational Cancer Center Research InstituteChuo-ku, Tokyo 104Japan

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