Experimental Stomach Carcinogenesis

  • Hiroko Ohgaki
  • Takashi Sugimura


Sugimura and Fujimura first succeeded in selective induction of gastric carcinomas in rats by putting N-methyl-N’-nitro-Nnitrosoguanidine (MNNG) in their drinking water in 1967. Since then, similar models have been established for the induction of stomach carcinomas in other species using MNNG and its ethyl derivative N-ethyl-N’-nitro-N-nitrosoguanidine (ENNG). N-Methyl-N-nitrosourea (MNU) has also been demonstrated to induce a high incidence of gastric adenocarcinomas in rats and mice when given in their drinking water. Susceptibility to gastric carcinogenesis and the histologic types of gastric carcinomas depend on the mode of treatment, species, strain, and sex. The organ specificity of MNNG correlates well with the level of DNA methylation in target and nontarget tissues following oral administration in rats. The high concentration of methylated DNA bases in the glandular stomach appears to result from thiol-mediated acceleration of the decomposition of MNNG. Experimental gastric carcinogenesis is greatly modified by various factors and agents, indicating that both host and environmental factors contribute significantly. Although possible gastric carcinogens in humans have not been clearly identified, results in experimental animals suggest that avoidance of factors that enhance stomach carcinogenesis, especially those that enhance cell proliferation in the gastric mucosa, could help prevent gastric carcinogenesis in humans.


Gastric Cancer Gastric Carcinoma Gastric Adenocarcinoma Intestinal Metaplasia Natl Cancer Inst 
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Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Hiroko Ohgaki
    • 1
  • Takashi Sugimura
    • 2
  1. 1.Unit of Molecular PathologyInternational Agency for Research on CancerLyonFrance
  2. 2.National Cancer Center Research InstituteChuo-ku, Tokyo 104Japan

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