Artificial Glycoconjugate Polymers: Cell-Specific Biomedical Materials Using Carbohydrates as Recognition Signals

  • Kazukiyo Kobayashi
  • Taichi Usui
  • Toshihiro Akaike


Well-defined polymers having mono- and oligosaccharide chains are of interest as biological probes and cell-specific biomedical materials. We prepared several oligosaccharide-substituted polymers of which chemical structures are shown in the next page. The main chains of the polymers are the derivatives of polystyrene (1–11, 18–21), Polyacrylamide (12–17), polypeptide (22), and polysaccharide (23). The starting mono- and oligosaccharides include glucose (1,12,21), mannose (14,23), N-acetylglucosamine (13), cellobiose (3), maltose (2), maltotriose (6), maltopentaose (7), maltoheptaose (8), amylose (9), lactose (4,16,17,19,20,22), melibiose (5), N-acetyllactosamine (15), N,N′-diacetylchitobiose(18), N,N′,N″-triacetylchitotriose(11), and so on.


Acrylic Acid Culture Substratum Oligosaccharide Chain Target Drug Delivery System Deprotection Step 
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    Kobayashi K, Kakishita N, Okada M, Akaike T, Usui T (1994) J. Carbohydr. Chem., 13: 753–766.CrossRefGoogle Scholar
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    Kobayashi K, Kobayashi A, Akaike T, In: Methods in Enzymology, Vol, 247 Neoglycoconjugates Part B Biomedical Applications, Lee YC, Lee RT (eds). Academic Press, San Diego, California 1994; pp 409–418.CrossRefGoogle Scholar
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    Kobayashi K, Tuchida A, Okada M, Akaike T, Usui T (1994) Polym .Prepr. Jpn., 43: 2857–2858.Google Scholar

Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • Kazukiyo Kobayashi
    • 1
  • Taichi Usui
    • 2
  • Toshihiro Akaike
    • 3
  1. 1.Faculty of Agricultural SciencesNagoya UniversityChikusa, NagoyaJapan
  2. 2.Faculty of AgricultureShizuoka UniversityShizuoka 836Japan
  3. 3.Faculty of Bioscience and TechnologyTokyo Institute of TechnologyMidori, Yokohama, 226Japan

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