Advertisement

Drug Releasing Mechanism from Redox Active Micelles

  • Yukikazu Takeoka
  • Takashi Aoki
  • Kohei Sanui
  • Naoya Ogata
  • Teruo Okano
  • Yasuhisa Sakurai
  • Masayoshi Watanabe
Conference paper

Summary

Electrochemical reaction of FPEG is coupled with the preceding disassembled reaction of micelles in aqueous solution. The change in diffusion species fromthe micelles to the monomers at cmc in the concentration gradient in diffusion layers appeared in case of bulk electrolysis of FPEG. The drug releasing mechanism from the redox active micelles were clarified.

Keywords

Electrode Reaction Aggregation Number Hydrophobic Drug Diffusion Species Drug Release Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    Saji T, (1988) Electrochemical formation of a phthalocyanine thin film by disruption of micellar aggregates. Chem. Lett., 693–696Google Scholar
  2. [2]
    Takeoka Y, Aoki T, Sanui K, Ogata N, Yokoyama M, Okano T, Sakurai Y (1995) Electrochemical control of drug release from redox-active micelles. J. Controlled Release, 33: 79–87CrossRefGoogle Scholar
  3. [3]
    Takeoka Y, Aoki T, Sanui K, Ogata N, Watanabe M, Electrochemical studies of a redox-active surfactants. Correlation between electrochemical responses and dissolved states. Langmuir, submitted.Google Scholar
  4. [4]
    Nicholson R S, Shain I (1964) Theory of stationary electrode polarography. Anal. Chem. 36:706–723CrossRefGoogle Scholar
  5. [5]
    Marcus R A (1963) On the theory of oxidation-reduction reactions involving electron transfer. V. Comparison and properties of electrochemical and chemical rate constants. J. Phys. Chem. 67: 853–857CrossRefGoogle Scholar
  6. [6]
    Marcus R A (1964) Chemical and electrochemical electron-transfer theory. Annu. Rev. Phys. Chem. 15: 155–196CrossRefGoogle Scholar
  7. [7]
    Marcus R A (1965) On the theory of electron-transfer reactions. VI. Unified treatment for homogeneous and electrode reactions. J. Chem. Phys. 43: 679–701CrossRefGoogle Scholar
  8. [8]
    Marcus R A, Sutin N (1985) Biochem. Biophys. Acta. 811: 265Google Scholar
  9. [9]
    Saji T, Hoshino K, Aoyagui S (1985) Reversible formation and disruption of micelles bycontrol of the redox state of the head group. J. Am. Chem. Soc. 107: 6865–6868CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • Yukikazu Takeoka
    • 1
  • Takashi Aoki
    • 1
  • Kohei Sanui
    • 1
  • Naoya Ogata
    • 1
  • Teruo Okano
    • 2
  • Yasuhisa Sakurai
    • 2
  • Masayoshi Watanabe
    • 3
  1. 1.Department of Chemistry, Faculty of Science and TechnologySophia UniversityTokyo 102Japan
  2. 2.Institute of Biomedical EngineeringTokyo Women’s Medical CollegeTokyo 162Japan
  3. 3.Department of ChemistryYokohama National UniversityYokohama 240Japan

Personalised recommendations