Effect of Micropore Structure on Drug Release Form Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent

  • Makoto Otsuka
  • Yoshihisa Matsuda
  • Jer Hsu
  • Jeffrey L. Fox
  • William I. Higuchi
Conference paper


The delivery of chemotherapeutic agents to bone via systemic routes of administration is problematic because of the serious side effects of these agents and the poor circulation to the bone. Hence, local delivery is an attractive option for these compounds.


Drug Release Calcium Phosphate Cement Drug Release Profile Drug Release Rate Cement System 
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Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • Makoto Otsuka
    • 1
  • Yoshihisa Matsuda
    • 1
  • Jer Hsu
    • 2
  • Jeffrey L. Fox
    • 2
  • William I. Higuchi
    • 2
  1. 1.Department of Pharmaceutical TechnologyKobe Pharmaceutical UniversityHigashi-Nada, Kobe 658Japan
  2. 2.Department of Pharmaceutics and Pharmaceutical ChemistryUniversity of UtahSalt Lake CityUSA

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