Perinatal Coagulation and Fibrinolysis

  • John Bonnar
  • Leisha Daly
  • Brian L. Sheppard


In normal pregnancy extensive changes take place in the hemostatic system, involving in particular the coagulation and fibrinolytic systems. These physiological changes seem to have two major interrelated functions. First, to maintain the integrity of the expanding maternal and fetal circulations at the interface of the placenta and, secondly, to ensure the rapid and effective control of bleeding from the placental site during and after placental separation.


Plasminogen Activator Inhibitor Normal Pregnancy Fibrin Deposition Spiral Artery Fibrin Degradation Product 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • John Bonnar
    • 1
  • Leisha Daly
    • 1
  • Brian L. Sheppard
    • 1
  1. 1.Trinity College Department of Obstetrics and GynaecologySt James’s Hospital and Coombe HospitalDublinIreland

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