Advertisement

Thrombin-Antithrombin III Complex and D-Dimer in Neonates

Signs of Thrombin Generation During Birth
  • W. Muntean
  • M. Danda
  • H. Rosegger

Abstract

In neonates, especially in sick neonates, signs of enhanced proteolysis are observed: (1) after birth the fibrinolytic activity is high, (2) fibrin/fibrinogen degradation products are elevated, and (3) fibrinogen is lower immediately after birth than after 3 days of life. Factor VIII activity is very high immediately after birth and activity of factor VIII is higher than factor VIII antigen suggesting activation of factor VIII [1–5].

Keywords

Factor Viii Thrombin Generation Fibrinolytic Activity Prothrombin Complex Concen Factor Viii Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ekelund H, Hender U, Nilsson IM (1970) Fibrinolysis in newborns. Acta Paediatr Scand 59: 33PubMedCrossRefGoogle Scholar
  2. 2.
    Henriksson P, Ekelund H (1975) Abnormal proteolysis in sich newborns. Acta Paediatr Scand 64: 327PubMedCrossRefGoogle Scholar
  3. 3.
    Muntean W (1980) Die Hämostase bei Frühgeborenen und reifen Neugeborenen. Padiatr Padol 15: 109PubMedGoogle Scholar
  4. 4.
    Muntean W, Belohradsky BH, Klose HJ, Riegel K (1977) Faktor-VIII-Aktivität und Faktor-Vlll-assoziiertes Antigen bei Neugeborenen. Klin Radiatr 189: 412Google Scholar
  5. 5.
    Sell EJ, Corrigan JJ (1973) Platelet count, fibrinogen concentration, and factor V and factor VIII level and healthy infants according to gestational age. J Pediatr 82: 1082CrossRefGoogle Scholar
  6. 6.
    Peter M, Cate JW, Breederveld C, De Leeuw R, Emeis J, Koppe J (1984) Low antithrombin III levels in neonates with idiopathic respiratory distress syndrome: poor prognosis. Pediatr Res 3: 273CrossRefGoogle Scholar
  7. 7.
    McDonald MM, Johnosn ML, Rumack CM, Koops BL, Guggenheim MA, Babb C, Hathaway WE (1984) Rolke of coagulopathy in newborn intracranial hemorrhage. Pedatrics 74: 26Google Scholar
  8. 8.
    Waltl H, Födisch HJ, Kurz R, Hohenauer L, Mitterstieler F, Rössler H (1973) Intracranial haemorrhage in low-birth-weight infants and prophylactic administration of coagulation-factor concentrate. Lancet II: 1284CrossRefGoogle Scholar
  9. 9.
    Pelzer H, Schwarz A, Heimburger N (1988) Determination of human thrombin antithrombin Ill-complex in plasma with an enzyme-linked immunosorbent assay. Thromb Haemost 59: 101PubMedGoogle Scholar
  10. 10.
    Belitser VA, Pozdnjakova TM, Platonova TN, Vouvk EV (1981) Fibrin-fragment-D-complex formation. Thromb Res 21: 565PubMedCrossRefGoogle Scholar
  11. 11.
    Muntean W, Rosegger H (1989) Antithrombin Ill-concentrate in preterm infants with IRDS: An open, controlled, randomized clinical trial. Thromb Haemost 62: 288aGoogle Scholar

Copyright information

© Springer Japan 1991

Authors and Affiliations

  • W. Muntean
    • 1
  • M. Danda
    • 1
  • H. Rosegger
    • 2
  1. 1.Department of Pediatrics, University of GrazUniversity of GrazGrazAustria
  2. 2.Department of Gynecology and ObstetricsUniversity of GrazGrazAustria

Personalised recommendations