Thrombin-Antithrombin III Complex and D-Dimer in Neonates

Signs of Thrombin Generation During Birth
  • W. Muntean
  • M. Danda
  • H. Rosegger


In neonates, especially in sick neonates, signs of enhanced proteolysis are observed: (1) after birth the fibrinolytic activity is high, (2) fibrin/fibrinogen degradation products are elevated, and (3) fibrinogen is lower immediately after birth than after 3 days of life. Factor VIII activity is very high immediately after birth and activity of factor VIII is higher than factor VIII antigen suggesting activation of factor VIII [1–5].


Factor Viii Thrombin Generation Fibrinolytic Activity Prothrombin Complex Concen Factor Viii Activity 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • W. Muntean
    • 1
  • M. Danda
    • 1
  • H. Rosegger
    • 2
  1. 1.Department of Pediatrics, University of GrazUniversity of GrazGrazAustria
  2. 2.Department of Gynecology and ObstetricsUniversity of GrazGrazAustria

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