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Six Cases of Alpha-1-Antitrypsin Deficiency Presenting as a Bleeding Diathesis with Intracranial Hemorrhage in the Newborn

  • Günter Auerswald
  • Anton H. Sutor
Conference paper

Abstract

Alpha-1-antitrypsin (alpha-1-AT), or alpha-1-protease inhibitor is a glycoprotein with a molecular weight of about 52. 000 daltons. More than 90% of it is synthesized by the liver. The concentration in serum in healthy children is 2.0–3.3 g/1. Alpha-1-AT constitutes about 90% of the whole alpha-1-globulin fraction. The gene responsible for the production of alpha-1-AT is situated on the long arm of chromosome 14.

Keywords

Intracranial Hemorrhage Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Prothrombin Complex Concentrate Bleeding Diathesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Günter Auerswald
    • 1
  • Anton H. Sutor
    • 2
  1. 1.Hess-KinderklinikBremen 1Federal Republic of Germany
  2. 2.Universitäts-KinderklinikFreiburg i.Br.Federal Republic of Germany

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