Advertisement

Analysis of γ-γ Dimer and Factor XIII (Fibrin Stabilizing Factor, FSF) During Pregnancy and Labor

  • Shigenori Suzuki
  • Henner Graeff
  • Reimar Hafter
Conference paper

Abstract

It is well known that the final stage of pregnancy is characterized by a state of hypercoagulability in which the levels of all coagulation factors, with the exception of factor XIII, increase. When fibrin and fibrinogen polymerize to form the matrix of the blood coagulation-fibrinolytic system, factor XIII, which acts like an adhesive, is the only coagulating factor that decreases. This perhaps suggests that the structure of the fibrin clot is weakened and that fibrinolysis increases.

Keywords

Factor Xiii Placenta Previa Fibrinogen Content Monochloroacetic Acid Fibrinogen Degradation Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Laki K, Lorand L (1948) On the solubility of fibrin clots. Science 108: 280PubMedCrossRefGoogle Scholar
  2. 2.
    Bohn H, Haupt H (1968) Eine quantitative Bestimmunge von Faktor XIII mit Anti-Faktor XlII-Serum. Thrombos Diathes Haemorrh (Stuttg) 9: 509Google Scholar
  3. 3.
    Blomback BM (1956) Purification of human and bovine fibrinogen. Arkiv Kemi 10: 415Google Scholar
  4. 4.
    Selingsohn U, Rapaport SJ, Kuefler PR (1972) Extra-adrenal effect of ACTH on fibrinogen synthesis. Am J Physiol 224: 1172Google Scholar
  5. 5.
    Ludwig H (1972) Thromboembolische Erkrankungen in der Schwanger schaft und unter Geburt. Z Geburtshilfe Perinatol 176, 3: 1169Google Scholar
  6. 6.
    Coopland A, Alkjaersig N, Fletcher A (1969) Reduction in plasma factor XIII (FSF) concentration during pregnancy. J Lab Clin Med 73, 1: 144PubMedGoogle Scholar
  7. 7.
    Suzuki S (1974) Consumption coagulopathy in obstetrics (in Japanese). Japanese Journal of Clinical Medicine 32, 5: 1077PubMedGoogle Scholar
  8. 8.
    Hafter K, Schneebaker T, Tafel K, Ernst E, Graef H (1971) Bestimmung von löslichen Fibrinmonomerkomplexen zur Erfassung der Hypercoagulabilität in der Schwangerschaft und unter der Geburt. Geburtshilfe Frauenheikd 35: 513Google Scholar
  9. 9.
    Triantaphyllopoulos DC (1973) The inactivation of factor XIII during blood coagulation. Thromb Res 3: 241CrossRefGoogle Scholar
  10. 10.
    Graeff HA, Wiedermann R, Von Hugo R, Hafter R (1976) Amount and distribution pattern of soluble fibrin monomer complexes during the early puerperium. Am J Obst Gynecol Vol 124, 1: 21Google Scholar

Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Shigenori Suzuki
    • 1
  • Henner Graeff
    • 2
  • Reimar Hafter
    • 2
  1. 1.College of Medical TechnologyHokkaido UniversityKita-ku, Sapporo 060Japan
  2. 2.Frauenklinik der Technischen Universität MünchenMünchen 80Federal Republic of Germany

Personalised recommendations