Time Interval Between Vitamin K Administration and Effective Hemostasis

  • Antoh H. Sutor
  • Wilhelm Künzer


In adults with vitamin K deficiency, correction of abnormal coagulation tests with vitamin K therapy cannot be expected for several hours; therefore, bleeding patients are given plasma concentrates to bridge the time before vitamin K becomes effective [1,2]. In newborns a time gap of several hours, in some instances up to 12 h, is reported [3,4]. The aim of the present study is to investigate the time interval between administration of vitamin K and, first, a significant increase of the PT value (in %) and, second, a demonstrable hemostatic effect to reverse the vitamin K deficiency bleeding with administration of vitamin K.


Prothrombin Time Biliary Atresia Prothrombin Complex Concentrate Hemostatic Effect Intravenous Vitamin 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Antoh H. Sutor
    • 1
  • Wilhelm Künzer
    • 1
  1. 1.Universitäts-KinderklinikFreiburgFederal Republic of Germany

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