Abstract
In adults with vitamin K deficiency, correction of abnormal coagulation tests with vitamin K therapy cannot be expected for several hours; therefore, bleeding patients are given plasma concentrates to bridge the time before vitamin K becomes effective [1,2]. In newborns a time gap of several hours, in some instances up to 12 h, is reported [3,4]. The aim of the present study is to investigate the time interval between administration of vitamin K and, first, a significant increase of the PT value (in %) and, second, a demonstrable hemostatic effect to reverse the vitamin K deficiency bleeding with administration of vitamin K.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Taberner DA, Thomson JM, Poller L (1976) Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal. Br Med J II: 83–85
Bartheis M, Poliwoda H (1987) Verminderung des Prothrombinkomplexes In: Bartheis M, Poliwoda H (eds) Gerinnungsanalysen. Thieme, Stuttgart, pp 63–72
Furie B (1983) Disorders of the vitamin K-dependent coagulation factors. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA (eds) Hematology, 3rd edn. McGraw-Hill, New York, pp 1421–1424
Hathaway WE, Bonnar J (1987) Hemostatic disorders of the pregnant woman and newborn infant. Wiley, Chichester, p 111
Sutor AH, Pollmann H, Kries R v, Brückmann C, Jörres H, Künzer W (1988) Spätform der Vitamin-K-Mangelblutung. Bericht über 57 Fälle. Sozialpädiatrie 10: 557–560
van Dam-Mieras MCE, Hemker HC (1983) Half-life time and control frequency of vitamin K’-dependent coagulation factors. Haemostasis 13: 201–208
McNinch AW, Upton C, Samuels M, Shearer MJ, McCarthy P, Tripp JH, Ormel’e R (1985) Plasma concentrations after oral or intramuscular vitamin K1 in neonates. Arch Dis Child 60: 814–818
Lefrère JJ, Girot R (1987) Acute cardiovascular collapse during intravenous vitamin K1 injection. Thromb Haemost 58: 790
Gädeke R (1989) Anmerkung zu dem Bericht von A.H. Sutor über den gegenwärtigen Stand der Vitamin-K-Prophylaxe. Pädiatr Prax 38: 632
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Japan
About this paper
Cite this paper
Sutor, A.H., Künzer, W. (1991). Time Interval Between Vitamin K Administration and Effective Hemostasis. In: Suzuki, S., Hathaway, W.E., Bonnar, J., Sutor, A.H. (eds) Perinatal Thrombosis and Hemostasis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65871-9_29
Download citation
DOI: https://doi.org/10.1007/978-4-431-65871-9_29
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-65873-3
Online ISBN: 978-4-431-65871-9
eBook Packages: Springer Book Archive