Abstract
In adults with vitamin K deficiency, correction of abnormal coagulation tests with vitamin K therapy cannot be expected for several hours; therefore, bleeding patients are given plasma concentrates to bridge the time before vitamin K becomes effective [1,2]. In newborns a time gap of several hours, in some instances up to 12 h, is reported [3,4]. The aim of the present study is to investigate the time interval between administration of vitamin K and, first, a significant increase of the PT value (in %) and, second, a demonstrable hemostatic effect to reverse the vitamin K deficiency bleeding with administration of vitamin K.
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References
Taberner DA, Thomson JM, Poller L (1976) Comparison of prothrombin complex concentrate and vitamin K1 in oral anticoagulant reversal. Br Med J II: 83–85
Bartheis M, Poliwoda H (1987) Verminderung des Prothrombinkomplexes In: Bartheis M, Poliwoda H (eds) Gerinnungsanalysen. Thieme, Stuttgart, pp 63–72
Furie B (1983) Disorders of the vitamin K-dependent coagulation factors. In: Williams WJ, Beutler E, Erslev AJ, Lichtman MA (eds) Hematology, 3rd edn. McGraw-Hill, New York, pp 1421–1424
Hathaway WE, Bonnar J (1987) Hemostatic disorders of the pregnant woman and newborn infant. Wiley, Chichester, p 111
Sutor AH, Pollmann H, Kries R v, Brückmann C, Jörres H, Künzer W (1988) Spätform der Vitamin-K-Mangelblutung. Bericht über 57 Fälle. Sozialpädiatrie 10: 557–560
van Dam-Mieras MCE, Hemker HC (1983) Half-life time and control frequency of vitamin K’-dependent coagulation factors. Haemostasis 13: 201–208
McNinch AW, Upton C, Samuels M, Shearer MJ, McCarthy P, Tripp JH, Ormel’e R (1985) Plasma concentrations after oral or intramuscular vitamin K1 in neonates. Arch Dis Child 60: 814–818
Lefrère JJ, Girot R (1987) Acute cardiovascular collapse during intravenous vitamin K1 injection. Thromb Haemost 58: 790
Gädeke R (1989) Anmerkung zu dem Bericht von A.H. Sutor über den gegenwärtigen Stand der Vitamin-K-Prophylaxe. Pädiatr Prax 38: 632
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© 1991 Springer Japan
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Sutor, A.H., Künzer, W. (1991). Time Interval Between Vitamin K Administration and Effective Hemostasis. In: Suzuki, S., Hathaway, W.E., Bonnar, J., Sutor, A.H. (eds) Perinatal Thrombosis and Hemostasis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65871-9_29
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DOI: https://doi.org/10.1007/978-4-431-65871-9_29
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-65873-3
Online ISBN: 978-4-431-65871-9
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