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Vitamin K Prophylaxis and Late Onset Hemorrhagic Disease of the Newborn in West Germany During 1988

  • Ulrich Göbel
  • Rüdiger von Kries
  • Christian Petrich
Conference paper

Abstract

Since 1980, an increased incidence of late onset hemorrhagic disease of the newborn has been noted in the Federal Republic of Germany. Details of these cases have been collected and the clinical data thoroughly analyzed by Sutor et al. [1,2]. The initially mysterious vitamin K deficient bleedings affected fully breast-fed infants who seemed in good health during the first three to seven weeks of life. In 1985 we described decreased absorption of vitamin K in an infant with late vitamin K deficiency and were able to relate this—as in some other cases—to minimal cholestasis as an underlying pathogenetic mechanism [3,4].

Keywords

Late Onset Federal Republic Pediatric Hospital Hemorrhagic Disease Anonymous Report 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sutor AH, Pancochar H, Niederhoff H, Pollmann H, Hilgenberg F, Palm D, Künzer W (1983) Vitamin K-Mangelblutungen bei vier vollgestillten Säuglingen im Alter von 4–6 Lebenswochen. Dtsch Med Wochenschr 108: 1635–1639PubMedCrossRefGoogle Scholar
  2. 2.
    Sutor AH, Pollmann H, Von Kries R, Brückmann C, Jörres H, Künzer W (1988) Spätform der Vitamin K-Mangelblutung. Sozialpädiatrie 10: 557–560Google Scholar
  3. 3.
    Von Kries R, McCarthy P, Shearer M, Göbel U (1985) Late onset haemorrhagic disease of newborn with temporary malabsorption of vitamin K1. Lancet I: 1035CrossRefGoogle Scholar
  4. 4.
    Von Kries R, Kreppel S, Becker A, Tangermann R, Göbel U (1987) Acarboxy-prothrombin detectability after oral prophylactic vitamin K. Arch Dis Child 62: 938–940CrossRefGoogle Scholar
  5. 5.
    Bergmann KH, Bremer HJ, Droese W, Grüttner R, Kübier W, Schmidt E, Schöch G (1986) Empfehlungen der Ernährungskommission der Deutschen Gesellschaft für Kinderheilkunde zur Vitamin K-Prophylaxe bei Neugeborenen. Monatsschr Kinderheilkd 134: 824–824Google Scholar
  6. 6.
    Sutor AH (1986) Spätmanifestation der Vitamin K-Mangelblutung bei vollgestillten Säuglingen. Kinderarzt 9: 1246–1250Google Scholar
  7. 7.
    Scharbau A, Sutor AH (1988) Ergebnisse der Freiburger Auswertung. In: Sutor AH, Göbel U (eds) Gegenwärtiger Stand der Vitamin K-Prophylaxe in Deutschland. Arbeitstagung Freiburg 10–11 July 1988. “Roche”, Basel, p 21Google Scholar
  8. 8.
    Von Kries R, Becker A, Göbel U (1987) Vitamin K in the newborn: influence of nutritional factors on acarboxy-prothrombin detectability and factor II and VII clotting activity. Eur J Pediatr 146: 123–127CrossRefGoogle Scholar
  9. 9.
    Motohara K, Matsukane I, Endo F, Kiyota Y, Matsuda I (1989) Relationship of milk intake and vitamin K-status in newborns. Pediatrics 84: 90–93PubMedGoogle Scholar
  10. 10.
    Tönz O (1988) Erfahrungen mit der Vitamin K-Prophylaxe in der Schweiz. In: Sutor AH, Göbel U (eds) Gegenwärtiger Stand der Vitamin K-Prophylaxe in Deutschland. Arbeitstagung Freiburg 10–11 July 1988. “Roche” Basel, pp 151–159Google Scholar
  11. 11.
    Göbel U, Bewersdorff S, Henninghausen B, Schmidt E (1986) Erniedrigte Prothrombin-Gerinnungsaktivitäten bei gestillten Kindern? Klin Padiatr 198: 13–16PubMedCrossRefGoogle Scholar
  12. 12.
    Matsuda I, Nishiyama S, Motohara K, Endo P, Ogata T, Futagoishi Y (1989) Late neonatal vitamin K deficiency associated with subclinical liver dysfunction in human milk-fed infants. J Pediatr 114: 602–605PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Ulrich Göbel
    • 1
  • Rüdiger von Kries
    • 1
  • Christian Petrich
    • 1
  1. 1.Abt. für Hämatologie und OnkologieKinderklinik der Heinrich-Heine-UniversitätDüsseldorf 1Federal Republic of Germany

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