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Thrombocytopenia Associated with Type IIB von Willebrand’s Disease of Pregnant Identical Twins

  • Masahiro Ieko
  • Megumi Yoshikawa
  • Shyouki Sakurama
  • Akira Sagawa
  • Tarou Yasukouchi
  • Shyoichi Nakagawa
Conference paper

Abstract

Type II B von Willebrand’s disease (vWD) is an inherited hemorrhagic disorder. The disease is characterized by the enhanced platelet aggregation at low ristocetin concentrations in the patient’s platelet-rich plasma (PRP). This characteristic suggests that type II B vWD may induce a marked decrease in the platelet count under some conditions. We found pregnant identical twin mothers with marked thrombocytopenia. The twins also had type IIB vW disease as well as systemic lupus erythematosus (SLE). We will report about these two cases with a recommendation for an appropriate therapy for thrombocytopenia associated with pregnancy in patients with type II B vWD disease.

Keywords

Systemic Lupus Erythematosus Platelet Count Factor Viii Sodium Dodecylbenzenesulfonate Factor VIII Related Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Masahiro Ieko
    • 1
  • Megumi Yoshikawa
    • 1
  • Shyouki Sakurama
    • 1
  • Akira Sagawa
    • 1
  • Tarou Yasukouchi
    • 2
  • Shyoichi Nakagawa
    • 1
  1. 1.Second Department of Internal MedicineHokkaido University School of MedicineSapporo, 060Japan
  2. 2.Department of Internal MedicineHigashi Nippon Gakuen University School of DentistryToubetsu, HokkaidoJapan

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