Thrombocytopenia Associated with Type IIB von Willebrand’s Disease of Pregnant Identical Twins
Type II B von Willebrand’s disease (vWD) is an inherited hemorrhagic disorder. The disease is characterized by the enhanced platelet aggregation at low ristocetin concentrations in the patient’s platelet-rich plasma (PRP). This characteristic suggests that type II B vWD may induce a marked decrease in the platelet count under some conditions. We found pregnant identical twin mothers with marked thrombocytopenia. The twins also had type IIB vW disease as well as systemic lupus erythematosus (SLE). We will report about these two cases with a recommendation for an appropriate therapy for thrombocytopenia associated with pregnancy in patients with type II B vWD disease.
KeywordsSystemic Lupus Erythematosus Platelet Count Factor Viii Sodium Dodecylbenzenesulfonate Factor VIII Related Antigen
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