Coagulation and Fibrinolytic Activity in Trophoblastic Disease
Trophoblastic disease can be mainly classified into hydatidiform mole, invasive mole, and choriocarcinoma. Since uterine bleeding is the most common symptom of trophoblastic disease, some patients may experience profuse bleeding after evacuation of a hydatidiform mole and bleeding from a vaginal lesion or metastatic foci of choriocarcinoma. Hydatidiform mole is one of the obstetric conditions associated with disseminated intravascular coagulation (DIC). Despite advances in the management of trophoblastic disease, hemorrhage remains a major risk in patients with trophoblastic disease. In this report, plasma concentrations of coagulation and fibrinolytic factors measured in patients with trophoblastic disease and a case report of a patient who died of DIC following chemotherapy immediately after expulsion of the mole are presented.
KeywordsDisseminate Intravascular Coagulation Disseminate Intravascular Coagulation Fibrinolytic Activity Hydatidiform Mole Molar Pregnancy
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- 1.Terada K (1981) Studies on hypercoagulable state and fibrinolytic activity in association with advanced gynecologic cancer. J Obstet Gynecol Neonatal Hematol 5: 179–199 (in Japanese)Google Scholar
- 4.Soma H, Malla D, Dali SM (1989) Clinical experience with trophoblastic diseases in Nepal. Jpn J Cancer Chemother 16: 1577–1581 (part II)Google Scholar
- 8.Åstedt B, Heimburger N (1988) Spezifisches Plasminogenaktivator-inhibitoren. Hamostaseologie 8: 233–239Google Scholar
- 9.Feinberg RF, Kliman HJ, Haimowitz JE, Queenan JT, Wun T-Ch, Strauss JF III (1988) Plasminogen activator inhibitor types 1 and 2 in human trophoblast. Proceedings of the 11th Rochester Trophoblast Conference with the European Placenta Group. abstract 106Google Scholar