Neonatal Thrombosis: A Critical Appraisal of the Available Evidence on Prevention, Diagnosis, and Treatment

  • Barbara Schmidt
  • Maureen Andrew
Conference paper


Thrombotic disease in newborn infants is common and serious enough to require effective and safe prevention and treatment [1]. However, thrombotic disease in newborns is also sufficiently rare to prompt anecdotal observations rather than controlled clinical trials. While there is an abundance of case reports in the pediatric literature, there is a conspicuous paucity of well-designed studies [2]. As a result, consensus about the appropriate prophylaxis and management of neonatal thrombosis is lacking [2]. In this article, we will examine the available evidence on the efficacy and safety of heparin prophylaxis in infants with indwelling umbilical artery catheters. We will also review the management of symptomatic thrombosis, using aortic thrombosis as an example. We begin with a description of the framework which will be used to assess the strength of evidence that supports current approaches to neonatal thrombosis.


Newborn Infant Umbilical Artery Thrombotic Complication Thrombotic Disease Catheter Patency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Barbara Schmidt
    • 1
  • Maureen Andrew
    • 1
  1. 1.Department of PediatricsMcMaster University Medical CentreHamiltonCanada

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