Regulatory Mechanisms Controlling Prothrombin and the Development of Blood Coagulation Factors During Gestation

  • C. Thomas Kisker
  • David Bohlken
  • Stanley Perlman
  • Ann Louise Olson
  • Jean Robillard
  • William Clarke


Disorders of blood coagulation are common in newborn infants. Major hemorrhage or thrombosis was found in 40% of neonatal deaths in one survey and intraventricular hemorrhage was detected in 26% of 101 autopsies of newborn infants in another [1,2]. Thus, problems related to hemorrhage and/or thrombosis play a major role in the mortality of newborn infants, particularly premature infants. The relationship between the increased risk for hemorrhage and thrombosis and abnormalities of blood coagulation is unclear. Decreased levels of blood coagulation factor activities in the newborn are less easily defined because the range of normal in the newborn is greater than in the adult and low levels of a number of blood coagulation factor activities based upon adult standards are present even in normal full-term newborns. Furthermore, the levels of many coagulation factors (including prothrombin and factors VII, IX, and X) differ depending on the gestational age of the infant with the lowest levels found in premature infants.


Blood Coagulation Coagulation Factor Newborn Infant Prothrombin Activity Blood Coagulation Factor 


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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • C. Thomas Kisker
    • 1
  • David Bohlken
    • 1
  • Stanley Perlman
    • 1
  • Ann Louise Olson
    • 1
  • Jean Robillard
    • 1
  • William Clarke
    • 1
  1. 1.Department of PediatricsUniversity of Iowa Hospitals and ClinicsIowa CityUSA

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