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Regulatory Mechanisms Controlling Prothrombin and the Development of Blood Coagulation Factors During Gestation

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Perinatal Thrombosis and Hemostasis

Abstract

Disorders of blood coagulation are common in newborn infants. Major hemorrhage or thrombosis was found in 40% of neonatal deaths in one survey and intraventricular hemorrhage was detected in 26% of 101 autopsies of newborn infants in another [1,2]. Thus, problems related to hemorrhage and/or thrombosis play a major role in the mortality of newborn infants, particularly premature infants. The relationship between the increased risk for hemorrhage and thrombosis and abnormalities of blood coagulation is unclear. Decreased levels of blood coagulation factor activities in the newborn are less easily defined because the range of normal in the newborn is greater than in the adult and low levels of a number of blood coagulation factor activities based upon adult standards are present even in normal full-term newborns. Furthermore, the levels of many coagulation factors (including prothrombin and factors VII, IX, and X) differ depending on the gestational age of the infant with the lowest levels found in premature infants.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA

    C. Thomas Kisker, David Bohlken, Stanley Perlman, Ann Louise Olson, Jean Robillard & William Clarke

Authors
  1. C. Thomas Kisker
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  2. David Bohlken
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  3. Stanley Perlman
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  4. Ann Louise Olson
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  5. Jean Robillard
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  6. William Clarke
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Editor information

Editors and Affiliations

  1. College of Medical Technology, Hokkaido University, Kita-ku, Sapporo 060, Japan

    Shigenori Suzuki M.D.

  2. University of Colorado School of Medicine, Denver, CO, 80262, USA

    William E. Hathaway M.D.

  3. Trinity College, Department of Obstetrics and Gynaecology, St. James’s Hospital, University of Dublin, Dublin, Ireland

    John Bonnar M.D., FRCOG

  4. Universitäts-Kinderklinik, 7800, Freiburg, Federal Republic of Germany

    Anton H. Sutor M.D.

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© 1991 Springer Japan

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Kisker, C.T., Bohlken, D., Perlman, S., Olson, A.L., Robillard, J., Clarke, W. (1991). Regulatory Mechanisms Controlling Prothrombin and the Development of Blood Coagulation Factors During Gestation. In: Suzuki, S., Hathaway, W.E., Bonnar, J., Sutor, A.H. (eds) Perinatal Thrombosis and Hemostasis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65871-9_13

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  • DOI: https://doi.org/10.1007/978-4-431-65871-9_13

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-65873-3

  • Online ISBN: 978-4-431-65871-9

  • eBook Packages: Springer Book Archive

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