Anticoagulant and Thrombolytic Therapy in the Newborn

  • Maureen Andrew
  • Barbara Schmidt


Pediatric thrombotic disease has its highest prevalence in the newborn period and contributes to both neonatal morbidity and mortality [1–3]. The thromboembolic complications are most frequently secondary to vascular catheters. However, spontaneous occlusion of both arterial and venous vessels in a variety of locations may also occur [2]. Currently, the anticoagulant drug, standard heparin (SH) is commonly used prophylactically to prevent catheter related thrombi [4]. Should a “clinically apparent” thromboembolic complication occur with significant limb or organ impairment, then anticoagulant and/or thrombolytic drugs are frequently used therapeutically to reestablish patency of the vessel or to prevent extension of the thrombi [5,6].


Thrombolytic Therapy Thrombin Generation Thromboembolic Complication Thrombolytic Agent Fibrinolytic System 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Maureen Andrew
    • 1
  • Barbara Schmidt
    • 1
  1. 1.Department of PediatricsMcMaster UniversityHamilton, OntarioCanada

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