Summary
We examined 128 primate Mhc class II DPB1 exon 2 sequences with special reference to the role of intragenic recombination in generating nucleotide diversity. The phylogenetic analysis shows that the beta-sheet coding region exhibits a trans-specific mode of evolution, while the alpha-helix coding region exhibits a monophyly of hominoids to OWMs (Old World Monkeys). Linkage among variable amino acid positions is tight in OWM sequences. In the hominoid alpha-helix coding region, however, amino acid sequence motifs are represented by fairly random combinations of several motifs in two subregions. The distribution of the number of nucleotide differences in all pairwise comparisons of DPB1 alleles is multimodal in OWMs, whereas it is unimodal in hominoids. The same analysis shows that the alpha-helix region tends to be more unimodal than the beta-sheet region. It is concluded that intragenic recombination has played more important roles in DPB1 diversity in hominoids than in OWMs.
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References
Bidwell JL, Lu P, Wang Y, Zhou K, Clay TM, Bontrop RE (1994) DRB, DQA, DQB, and DPB nucleotide sequences of Saguinus oedipus B95–8. Eur J Immunogenet 21: 67–77
Bontrop RE, Otting N, Slierendregt BL, Lanchbury JS (1995) Evolution of major histocompatibility complex polymorphism and T-cell receptor diversity in primates. Immunol Rev 143: 33–62
Di Rienzo A, Wilson AC (1991) Branching pattern in the evolutionary tree for human mitochondrial DNA. Proc Natl Acad Sci USA 88: 1597–1601
Gyllensten U, Sundvall M, Erlich HA (1991) Allelic diversity is generated by intraexon exchange at class II Mhc DRB 1 locus of primates. Proc Natl Acad Sci USA 88: 3686–3690
Gyllensten U, Bergstrom T, Josefsson A, Sundvall M, Erlich HA (1996) Rapid allelic diversification and intensified selection at antigen recognition sites of the Mhc class II DPB 1 locus during hominid evolution. Tissue Antigens 47: 212–221
Hashiba K, Kuwata S, Tokunaga K, Juji T, Noguchi A (1993) Sequence analysis of DPBI-like genes in cynomolgus monkeys (Macaca fascicularis). Immunogenetics 38: 462
Hughes AL, Nei M (1988) Pattern of nucleotide substitutions at major histocompatibility complex class I loci reveals overdominant selection. Nature 335: 167–170
Hughes AL, Nei M (1989) Nucleotide substitution at major histocompatibility complex class II loci: Evidence for overdominant selection. Proc Nat! Acad Sci USA 86: 958–962
Jakobsen IB, Wilson SR, Easteal S (1998) Patterns of reticulate evolution for the classical class I and II HLA loci. Immunogenetics 48: 312–323
Kingman JFC (1982) On the genealogy of large populations. J Appl Prob 19A: 27–43
Klein J (1980) Generation of diversity at MHC loci: Implications for T cell receptor repertoires. In: Fougereau J, Dausset J (eds) Immunology 80. Progress in Immunology I V. Academic Press, London
Klein J, Figueroa F (1986) Evolution of the major histocompatibility complex. Crit Rev Immunol 6: 295–386
Klein J, O’hUigin C (1995) Class II Mhc motifs in an evolutionary perspective. Immunol Rev 143: 89–111
Klein J, Satta Y, O’hUigin C, Takahata N (1993) The molecular descent of the major histocompatibility complex. Annu Rev Immunol 11: 269–295
Lawlor DA, Zemmour J, Ennis PD, Parham P (1990) Evolution of class-I MHC genes and proteins: from natural selection to thymic selection. Annu Rev Immunol 8: 23–63
Martin RD (1993) Primate origins, plugging the gaps. Nature 363: 223–234
Mitsunaga S, Kuwata S, Tokunaga K, Uchikawa C, Takahashi K, Akaza T, Mitomi Y, Juji T (1992) Family study on HLA-DPBI polymorphism: linkage analysis with HLA-DR/DQ and two “ new ” alleles. Hum Immunol 34: 203–211
Otting N, Doxiadis GGM, Versluis L, de Groot NG, Anholts J, Verduin W, Rozenmuller E, Claas F, Tilanus MGJ, Bontrop RE (1998) Characterization and distribution of Mhc-DPB 1 alleles in chimpanzee and rhesus macaque populations. Hum Immunol 59: 636–664
Parham P, Ohta T (1996) Population biology of antigen presentation by MHC class I molecules. Science 272: 67–73
Saitou N, Nei M (1987) The neighbor-joining method: A new method for reconstructing phylogenetic trees. Mol Biol Evol 4: 406–425
Satta Y (1997) Effects of intra-locus recombination on HLA polymorphism. Hereditas 127: 105–112
Satta Y, O’hUigin C, Takahata N, Klein J (1994) Intensity of natural selection at the major histocompatibility complex loci. Proc Natl Acad Sci USA 91: 7144–7188
Satta Y, Klein J, Takahata N (1999) DNA archives and our nearest relative: The trichotomy problem revisited. Mol Phyl Evol (in press)
Slatkin M, Hudson RR (1991) Pairwise comparisons of mitochondrial DNA sequences in stable and exponentially growing populations. Genetics 129: 555–562
Slierendregt BL, Otting N, Kenter M, Bontrop RE (1995) Allelic diversity at the MhcDP locus in rhesus macaques (Macaca mulatta). Immunogenetics 41: 29–37
Takahata N (1990) A,simple genealogical structure of strongly balanced allelic lines and trans-species evolution of polymorphism. Proc Natl Acad Sci USA 87: 2419–2423
Takahata N (1999) Molecular phylogeny and demographic history of humans. The Proceedings of the Dual Congress (in press)
Takahata N, Nei M (1990) Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci. Genetics 124: 967–978
Takahata N, Satta Y (1998) Selection, convergence, and intragenic recombination in HLA diversity. Genetica 102 /103: 157–169
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Hashiba, K., Mitsunaga, S., Tokunaga, K., Satta, Y. (2000). Evolution of Catarrhini DPB1 exon 2 under intragenic recombination. In: Kasahara, M. (eds) Major Histocompatibility Complex. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65868-9_29
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DOI: https://doi.org/10.1007/978-4-431-65868-9_29
Publisher Name: Springer, Tokyo
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