Summary
Human chromosomes 1, 9, and 19 contain the regions paralogous to the major histocompatibility complex (MHC). Since our initial description, the number of gene families with copies in the MHC and these paralogous regions has been increasing steadily and now counts 37. There are at least 50 gene families that do not have copies in the MHC but share paralogous copies among the paralogous regions on chromosomes 1, 9, and 19, or between two of them. Thus, the MHC paralogous group is made up of more than 80 gene families with diverse structures, functions, and patterns of expression. Here we present the updated listing of gene families constituting this paralogous group. Systematic identification of the members of the MHC paralogous group offers a unique opportunity to deduce the organization of the primordial MHC, and to study the fate of duplicated genes.
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References
Abi Rached L, McDermott MF, Pontarotti P (1999) The MHC big bang. Immunol Rev 167: 33–44
Du Pasquier L, Flajnik MF (1998) Origin and evolution of the vertebrate immune system. In: Paul WE (ed) Fundamental Immunology. 4th ed. Lippincott-Raven, Philadelphia-New York, pp 605–650
Endo T, Imanishi T, Gojobori T, Inoko H (1997) Evolutionary significance of intra-genome duplications on human chromosomes. Gene 205: 19–27
Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo RJ, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR, Wolff RK (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13: 399–408
Flajnik MF, Ohta Y, Namikawa-Yamada C, Nonaka M (1999) Insights into the primordial MHC from studies in ectothermic vertebrates. Immunol Rev 167: 59–67
Hallböök F, Lundin L-G, Kullander K (1998) Lampetra Jluviatilis neurotrophin homolog, descendant of a neurotrophin ancestor, discloses the early molecular evolution of neurotrophins in the vertebrate subphylum. J Neurosci 18: 8700–871 I
Hughes AL (1998) Phylogenetic tests of the hypothesis of block duplication of homologous genes on human chromosomes 6, 9, and 1. Mol Biol Evol 15: 854–870
Kasahara M (1997) New insights into the genomic organization and origin of the major histocompatibility complex: Role of chromosomal (genome) duplication in the emergence of the adaptive immune system. Hereditas 127: 59–65
Kasahara M (1998) What do the paralogous regions in the genome tell us about the origin of the adaptive immune system? Immunol Rev 166: 159–175
Kasahara M (1999a) The chromosomal duplication model of the major histocompatibility complex. Immunol Rev 167: 17–32
Kasahara M (I 999b) Genome dynamics of the major histocompatibility complex: insights from genome paralogy. Immunogenetics 49:in press
Kasahara M (1999e) Genome paralogy: A new perspective on the organization and origin of the major histocompatibility complex. Curr Top Microbiol Immunol 248:in press
Kasahara M, Flajnik MF, Ishibashi T, Natori T (1995) Evolution of the major histocompatibility complex: a current overview. Transplant Immunol 3: 1–20
Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T, Ishibashi T (1996) Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proc Natl Acad Sci USA 93: 9096–9101
Kasahara M, Nakaya J, Satta Y, Takahata N (1997) Chromosomal duplication and the emergence of the adaptive immune system. Trends Genet 13: 90–92
Katsanis N, Fitzgibbon J, Fischer EMC (1996) Paralogy mapping: Identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci. Genomics 35: 101–108
Klein J, Sato A (1998) Birth of the major histocompatibility complex. Scand J Immunol 47: 199–209
Litman GW, Anderson MK, Rast JP (1999) Evolution of antigen binding receptors. Annu Rev Immunol 17: 109–147
Lundin LG (1993) Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse. Genomics 16: 1–19
Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (1996) The three genes of the human FCGRI gene family encoding FcyRl flank the centromere of chromosome 1 at 1 p 12 and 1q21. Cytogenet Cell Genet 73: 157–163
Nadeau JH, Kosowsky M (1991) Mouse map of paralogous genes. Mamm Genome 1: S433 - S460
Ohno S (1970) Evolution by Gene Duplication. Springer-Verlag. New York
Ollenuorff V, Mattei M-G, Fournier E, Adelaide J, Lopez M. Rosnet O, Birnbaum D (1998) A third human CBL gene is on chromosome 19. Int 1 Oncol 13: 1159–1161
Patton SJ, Luke GN, Holland PWFI (1998) Complex history of a chromosomal paralogy region: Insights from amphioxus aromatic amino acid hydroxylase genes and insulinrelated genes. Mol Biol Evol 15: 1373–1380
Pébusque M-J, Coulier F, Birnbaum D, Pontarotti P (1998) Ancient large-scale genome duplications: phylogenetic and linkage analyses shed light on chordate genome evolution. Mol Biol Evol 15: 1145–1159
Postlethwait JH, Yan Y-L, Gates MA, Home S, Amores A, Brownlie A, Donovan A, Egan ES, Force A, Gong Z, Goutel C, Fritz A, Kelsh R, Knapik E, Liao E, Paw B, Ransom D, Singer A, Thomson M, Abduljabbar TS, Yelick P, Beier D, Jol, J-S, Larhammar D, Rosa F, Westerfield M, Zon LI, Johnson SL, Talbot WS (1998) Vertebrate genome evolution and the zebrafish gene map. Nat Genet 18: 345–349
Ruddle FH, Bentley KL, Murtha MT, Risch N (1994) Gene loss and gain in the evolution of the vertebrates. Development 1994 Suppl: 155–161
Ruvinsky I, Silver LM (1997) Newly identified paralogous groups on mouse chromosomes 5 and 11 reveal the age of a T-box cluster duplication. Genomics 40: 262–266
Sharman AC, Holland PWH (1996) Conservation, duplication, and divergence of developmental genes during chordate evolution. Netherlands J Zool 46: 47–67
Sidow A (1996) Gen(om)e duplications in the evolution of early vertebrates. Curr Opin Genet Dev 6: 715–722
Spring J (1997) Vertebrate evolution by interspecific hybridization–are we polyploid? FEBS Lett 400: 2–8
Takami K, Zaleska-Rutczynska Z, Figueroa F, Klein J (1997) Linkage of LMP, TAP, and R1NG3 with Mhc class I rather than class Il genes in the zebrafish. J Immunol 159: 6052–6060
Trachtulec Z, Hamvas RMJ, Forejt J, Lehrach HR, Vincek V, Klein J (1997) Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates. Genomics 44: 1–7
Yunis JJ (1982) The origin of man: a chromosomal pictorial legacy. Science 215: 1525–1530
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Kasahara, M., Yawata, M., Suzuki, T. (2000). The MHC paralogous group: listing of members and a brief overview. In: Kasahara, M. (eds) Major Histocompatibility Complex. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65868-9_2
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DOI: https://doi.org/10.1007/978-4-431-65868-9_2
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