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Bioprobes pp 1-10 | Cite as

Trends in Bioprobe Research

  • Hiroyuki OsadaEmail author
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Abstract

The term “bioprobe” was used for the first time in the previous version of this book [1]. Bioprobes were defined as small molecules which are useful not only for biochemical research but also for the source of drug candidates with diverse activities. Historically, microbial metabolites have been quite useful not only as medicines but also as bioprobes. As a typical example, penicillin was originally discovered as a therapeutic agent against bacterial infectious diseases. Afterwards, research on the mode of action of penicillin gave us the insight on the structure and the biosynthesizing mechanism of the bacterial cell wall [2, 3]. Another well-known example is that the reverse transcriptase was discovered by the aid of daunomycin and actinomycin D. In the twentieth century, the central dogma of molecular biology suggested that the genetic information flows from DNA to RNA, and then finally to protein. However, some tumor viruses transcribe DNA from RNA by reverse transcriptase which is RNA-dependent DNA polymerase [4, 5]. Specific inhibitors of DNA and RNA synthesis were used to prove the template of the polymerase.

Keywords

Screening PPI Target Identification Cell Morphology Profiling Proteome Affinity Beads DARTS CETSA 
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© Springer Japan KK 2017

Authors and Affiliations

  1. 1.Chemical Biology Research GroupRIKEN Center for Sustainable Resource ScienceWakoJapan

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