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Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds pp 399–409Cite as

Related Topic: Drug Permeation Through Hair Follicles

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Abstract

The skin is focused on as the site of application of drugs and cosmetics. The pathway for the permeation of therapeutic and cosmeceutical chemicals through the skin is thus very important in evaluating their effects. Many reports have been published describing the importance of skin appendages such as hair follicles and sweat glands as permeation/penetration pathways, especially for hydrophilic compounds and macromolecules. Furthermore, hair follicles are an important drug delivery site for anti-acne and androgenetic alopecia agents. In addition to local therapeutic effects, there is the possibility of systemic therapeutic drug delivery since an extensive capillary blood network exists in the upper follicles and dermal papilla regions. Therefore, knowledge of the pharmacokinetics of topically applied drugs in the hair follicle is necessary for the development of pharmaceutical formulations as well as for evaluating their effects in terms of safety. The aim of this chapter is to describe the role of the hair follicle in the drug or chemical penetration process and to show the contribution of the hair follicular pathway to the total skin permeation of topically applied and exposed chemicals.

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Authors and Affiliations

  1. Faculty of Pharmacy and Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama, 350-0295, Japan

    Hiroaki Todo

  2. School of Pharmacy, Management & Science University, University Drive, Off Persiaran Olahraga, Section 13, 40100, Shah Alam, Selangor Darul Islam, Malaysia

    Fadli Mohd

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  1. Hiroaki Todo
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  2. Fadli Mohd
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Correspondence to Hiroaki Todo .

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Editors and Affiliations

  1. President, Josai International University, Togane, Chiba, Japan

    Kenji Sugibayashi

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Todo, H., Mohd, F. (2017). Related Topic: Drug Permeation Through Hair Follicles. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_36

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