Abstract
Some physical penetration-enhancing techniques may create permeation routes in the skin barrier, which may involve water channels for the hydrophilic drugs. In those processes, diffusion in the channels is the major mechanism of transport, and thus, the diffusion coefficient (D) in aqueous medium could be a primary factor for assessing permeation through the skin barrier. Several experimental methods to determine D for chemical compounds in water or other solvents are described in this chapter.
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Seki, T., Miki, R. (2017). Related Topic: Measurement of Diffusion Coefficient of Chemicals. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_33
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DOI: https://doi.org/10.1007/978-4-431-56526-0_33
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