Abstract
Drug products applied to the skin can be subdivided into two categories: One is the dermatological formulations (cream, ointments, gels, lotions) intended for the treatment of local skin disorders; the other is the transdermal delivery systems (ointments and patches) intended for the treatment or prevention of systemic disease.
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References
Anderson RL, Cassidy JM (1973) Variation in physical dimensions and chemical composition of human stratum corneum. J Invest Dermatol 61:30–32
Holbrook KA, Odland GF (1974) Regional differences in the thickness (cell layers) of the human stratum corneum: an ultrastructural analysis. J Invest Dermatol 62:415–422
Kalia YN, Guy RH (2001) Modeling transdermal drug release. Adv Drug Deliv Rev 48:159–172
Gabrielsson J, Weiner D (2007) Pharmacokinetic and pharmacodynamic data analysis: concepts and applications, 4th edn. Swedish Pharmaceutical Press, Sweden, pp 759–761
Alberti I, Kalia YN, Naik A, Guy RH (2001) Assessment and prediction of the cutaneous bioavailability of topical terbinafine, in vivo, in man. Pharm Res 18:1472–1475
Benfeldt E, Hansen SH, Vølund A, Menné T, Shah VP (2007) Bioequivalence of topical formulations in humans: evaluation by dermal microdialysis sampling and the dermatopharmacokinetic method. J Invest Dermatol 127:170–178
Sato K, Oda T, Sugibayashi K, Morimoto Y (1988) Estimation of blood concentration of drugs after topical application from in vitro skin permeation data. I. Prediction by convolution and confirmation by deconvolution. Chem Pharm Bull 36:2232–2238
Dias M, Naik A, Guy RH, Hadgraft J, Lane ME (2007) In vivo infrared spectroscopy studies of alkanol effects on human skin. Eur J Pharm Biopharm 69:1171–1175
Wojciechowski Z, Pershing LK, Huether S, Leonard L, Burton SA, Higuchi WI, Krueger GG (1987) An experimental skin sandwich flap on an independent vascular supply for the study of percutaneous absorption. J Invest Dermatol 88:439–446
Bito L, Davson H, Levin E, Murray M, Snider N (1966) The concentrations of free amino acids and other electrolytes in cerebrospinal fluid, in vivo dialysate of brain, and blood plasma of the dog. J Neurochem 13:1057–1067
Banga AK (2011) Transdermal and intradermal delivery of therapeutic agents: application of physical technologies, 1st edn. CRC Press, p 40
Benfeldt E, Serup J, Menné T (1999) Microdialysis vs. suction blister technique for in vivo sampling of pharmacokinetics in the human dermis. Acta Derm Venereol 79:338–342
Anderson C, Andersson T, Molander M (1991) Ethanol absorption across human skin measured by in vivo microdialysis technique. Acta Derm Venereol 71:89–93
Holmgaard R, Benfeldt E, Nielsen JB, Gatschelhofer C, Sorensen JA, Höfferer C, Bodenlenz M, Pieber TR, Sinner F (2002) Comparison of open-flow microperfusion and microdialysis methodologies when sampling topically applied fentanyl and benzoic acid in human dermis ex vivo. Pharm Res 29:1808–1820
Tettey-Amlalo RN, Kanfer I, Skinner MF, Benfeldt E, Verbeeck RK (2009) Application of dermal microdialysis for the evaluation of bioequivalence of a ketoprofen topical gel. Eur J Pharm Sci 36:219–225
Schnetz E, Fartasch M (2001) Microdialysis for the evaluation of penetration through the human skin barrier – a promising tool for future research? Eur J Pharm Sci 12:165–174
Herkenne C, Naik A, Kalia YN, Hadgraft J, Guy RH (2007) Dermatopharmacokinetic prediction of topical drug bioavailability in vivo. J Invest Dermatol 127:887–894
Wiedersberg S, Naik A, Leopold CS, Guy RH (2009) Pharmacodynamics and dermatopharmacokinetics of betamethasone 17-valerate: assessment of topical bioavailability. Br J Dermatol 160:676–686
Puttnam NA (1972) Attenuated total flectance studies of the skin. J Soc Cosmet Chem 23:209–226
Knutson K, Pott RO, Guzek DB, Golden GM, McKie JE, Lambert WJ, Higuchi WI (1985) Macro- and molecular physical-chemical considerations in understanding drug transport in the stratum corneum. J Control Release 2:67–87
Alberti I, Kalia YN, Naik A, Bonny J, Guy RH (2001) Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo. Int J Pharm 219:11–19
Potts RO, Guzek DB, Harris RR, McKie JE (1985) A noninvasive, in vivo technique to quantitatively measure water concentration of the stratum corneum using attenuated total-reflectance infrared spectroscopy. Arch Dermatol Res 277:489–495
Harrison JE, Watkinson AC, Green DM, Hadgraft J, Brain K (1996) The relative effect of Azone and Transcutol on permeant diffusivity and solubility in human stratum corneum. Pharm Res 13:542–546
Pirot F, Kalia YN, Stinchcomb AL, Keating G, Bunge A, Guy RH (1997) Characterization of the permeability barrier of human skin in vivo. Proc Natl Acad Sci USA 94:1562–1567
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Watanabe, T. (2017). In Vivo Methods. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_30
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DOI: https://doi.org/10.1007/978-4-431-56526-0_30
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