Abstract
Cyclodextrins (CDs) are cyclic oligosaccharide products of enzymatic starch degradation. Native CDs comprise 6, 7, or 8 D-glucose units linked by α-1,4 bonds, and are known as α-, β-, and γ-CDs, respectively (Fig. 19.1). Although CDs are hydrophilic due to the presence of multiple hydroxyl groups, hydrophobic cavities of C-C bonds and C-O bonds allow formation of inclusion complexes with hydrophobic molecules [1]. Thus, CDs are used as host compounds that improve the solubility and stability of pharmaceutical, cosmeceutical, and food additives. Among CDs, β-CD has been widely used for its strong inclusion efficacy and low cost, but has limited solubility in water. Thus, modified β-CDs including sulfobutyl ether-β-CD, hydroxypropyl-β-CD, maltosyl-β-CD, and methylated-β-CD have been developed [2, 3]. In addition, recently decreasing costs of native α- and γ-CDs are leading to wider applications and various CDs have been widely used as pharmaceutical excipients for oral, parenteral, ophthalmic, nasal, and dermal formulations [4, 5]. Currently, more than 40 CD-containing pharmaceutical products are marketed globally [6].
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Egawa, Y., Seki, T. (2017). Related Topic: Cyclodextrin. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_19
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DOI: https://doi.org/10.1007/978-4-431-56526-0_19
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