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Adult T-cell Leukemia/Lymphoma pp 117–124Cite as

Treatment of Indolent Adult T-cell Leukemia/Lymphoma (ATL)

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Abstract

Indolent adult T-cell leukemia-lymphoma (ATL) is consisted of a smoldering type and a favorable chronic type. The 4-year overall survival (OS) of smoldering and favorable ATL has been found to be 52% and 60%, respectively, by a Japanese retrospective survey. However, no solid information has been acquired from prospective trials in determining an appropriate standard of care, although an International Consensus Meeting has recommended considering combination treatment of interferon-α and zidovudine or watchful waiting if patients are symptomatic, or watchful waiting alone if patients are asymptomatic. In addition, local therapy such as skin-directed therapy using topical steroids, ultraviolet B treatment, psoralen photochemotherapy, electron beam therapy, radiation therapy, or single-agent chemotherapy by etoposide or sobuzoxane has been incorporated in practice with indeterminate survival benefit. The optimal treatment for indolent ATL has not yet been determined; thus, conducting prospective studies in this cohort of patients is of great importance.

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Authors and Affiliations

  1. Division of Hematology and Immunology, Center for Chronic Viral Disease, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

    Kenji Ishitsuka

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  1. Kenji Ishitsuka
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Correspondence to Kenji Ishitsuka .

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Editors and Affiliations

  1. Department of Medical Genome Sciences Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan

    Toshiki Watanabe

  2. Department of Clinical Laboratory Sciences School of Health Sciences, University of the Ryukyus, Okinawa, Japan

    Takuya Fukushima

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Ishitsuka, K. (2017). Treatment of Indolent Adult T-cell Leukemia/Lymphoma (ATL). In: Watanabe, T., Fukushima, T. (eds) Adult T-cell Leukemia/Lymphoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56523-9_9

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  • DOI: https://doi.org/10.1007/978-4-431-56523-9_9

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  • Print ISBN: 978-4-431-56521-5

  • Online ISBN: 978-4-431-56523-9

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