New Agents of Adult T-cell Leukemia/Lymphoma (ATL)

Chapter

Abstract

Adult T-cell leukemia-lymphoma (ATL) is a malignancy of peripheral T lymphocytes caused by an RNA retrovirus, human T-cell leukemia virus type I (HTLV-1). ATL remains difficult to cure and has an extremely poor prognosis with conventional chemotherapy; therefore, there is an unmet medical need for novel drugs. CC chemokine receptor 4 (CCR4) is expressed on the tumor cells of most of ATL patients and was considered to be a promising therapeutic target. Mogamulizumab, a defucosylated, humanized anti-CCR4 monoclonal antibody, was developed using a novel glycoengineering technology that remarkably enhances antibody-dependent cell-mediated cytotoxic activity. Mogamulizumab monotherapy achieved a high response rate in patients with relapsed ATL, with an acceptable toxicity profile. Furthermore, dose-intensified combination chemotherapy with mogamulizumab is a promising treatment option for untreated patients with aggressive ATL. In addition, lenalidomide has shown the promising antitumor activity in patients with ATL.

Keywords

Adult T-cell leukemia-lymphoma ATL CCR4 Mogamulizumab Lenalidomide 

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Copyright information

© Springer Japan KK 2017

Authors and Affiliations

  1. 1.Department of HematologyNational Cancer Center HospitalTokyoJapan

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