• Toshiki Watanabe
  • Takuya Fukushima


The disease entity of adult T-cell leukemia-lymphoma (ATL) was proposed by Takatsuki et al. in 1977, and human T-cell leukemia virus type I (HTLV-1) was discovered as the causative virus of ATL in the early 1980s. Since then, many researchers—especially in Japan where it is endemic with the highest prevalence in the world—have been investigating and clarifying its many features including the epidemiology of HTLV-1, the molecular mechanisms of the progression from HTLV-1 infection to ATL, and the development of more effective treatment for ATL.


Hematopoietic Stem Cell Transplantation Disease Entity Clonal Growth Allogeneic Hematopoietic Stem Cell Transplantation Pathogenetic Role 
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Copyright information

© Springer Japan KK 2017

Authors and Affiliations

  1. 1.Department of Medical Genome Sciences, Graduate School of Frontier SciencesThe University of TokyoTokyoJapan
  2. 2.Department of Clinical Laboratory Sciences, School of Health SciencesUniversity of the RyukyusOkinawaJapan

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