Abstract
This chapter describes a functional adaptation of cancellous bone at the macroscopic level by considering the microscopic cellular activities through a computational approach. We simulate the morphological changes in a cancellous bone specimen consisting of multiple trabeculae in response to external loadings. The remodeling simulation predicts the reorientation of trabeculae parallel to the loading direction, leading to the uniformalization of the mechanical state in the cancellous bone. This result implies that our model of remodeling, in which flow stimuli to osteocytes are assumed to be a driving force of bone remodeling, can represent the phenomenological law of bone transformation toward a locally uniform state of stress or strain at the trabecular level.
This Chapter was adapted from Kameo and Adachi (2014) with permission from Springer.
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Kameo, Y., Tsubota, Ki., Adachi, T. (2018). Cancellous Bone Adaptation Predicted by Remodeling Simulations. In: Bone Adaptation. Frontiers of Biomechanics, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56514-7_7
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