Abstract
In this chapter, we provide a mathematical model for trabecular bone remodeling that incorporates the possible mechanisms of cellular mechanosensing and intercellular communication. This model postulates that osteocytes, as mechanosensory cells, are stimulated by interstitial fluid flow to regulate bone adaptation. The morphological changes in trabeculae, in response to the mechanical environment, are demonstrated with the help of a voxel finite element method. The validity of the proposed mathematical model is tested through a remodeling simulation for a single trabecula subjected to cyclic uniaxial loading at various frequencies.
This Chapter was adapted from Kameo et al. (2011) with permission from Elsevier.
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Kameo, Y., Tsubota, Ki., Adachi, T. (2018). Modeling Trabecular Bone Adaptation Induced by Flow Stimuli to Osteocytes. In: Bone Adaptation. Frontiers of Biomechanics, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56514-7_5
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