Abstract
Genomics and transcriptomics research of the brain, accelerated by the development of sequencing technologies and genomic analysis methods, can reveal the genetic mechanisms underlying brain function, evolution, and development in various animals. This chapter first introduces the background of the recent technology of sequencing machines and analytical methods by bioinformatics, which makes possible the large-scale study of brains, and then presents recent results and achievements for brain function and evolution. Recent studies utilizing these emerging technologies are also introduced to demonstrate the power of large-scale analysis of genome and transcriptome for brain research. A perspective of international research projects for brain function is also introduced in the last section.
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Adams MD et al (1991) Complementary DNA sequencing: expressed sequence tags and human genome project. Science 252(5013):1651–1656
Adams MD et al (2000) The genome sequence of Drosophila melanogaster. Science 287(5461):2185–2195
Albertin CB et al (2012) Cephalopod genomics: a plan of strategies and organization stand. Genomic Sci 7:175–188
Blattner FR et al (1997) The complete genome sequence of Escherichia coli K-12. Science 277:1453–1462
Cahoy JD et al (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28(1):264–278
Carro MS et al (2010) The transcriptional network for mesenchymal transformation of brain tumours. Nature 463:318–325
Chin J et al (2014) SMRT® sequencing solutions for large genomes and transcriptomes. J Biomol Tech 25(suppl):S15
Goffeau A et al (1997) The yeast genome directory. Nature 387:5–105
Goymer P (2007) Alternative splicing switches on the brain. Nat Rev Genet 8:572
Hang G et al (2014) Genomics in neurological disorders. Genomics Proteomics Bioinformatics 12(4):156–163
International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature 409(6822):860–921
Kang HJ et al (2011) Spatio-temporal transcriptome of the human brain. Nature 478:483–489
Kapranov P et al (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316(5830):1484–1488
Khaitovich P et al (2005) Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees. Science 309:1850
Koonin EV (2005) Orthologs, paralogs, and evolutionary genomics. Annu Rev Genet 39:309–338
Levene MJ (2003) Zero-mode waveguides for single-molecule analysis at high concentrations. Science 299(5607):682–686
Margulies M et al (2005) Genome sequencing in microfabricated high-density picolitre reactors. Nature 437:376–380
Martin JA, Wang Z (2011) Next-generation transcriptome assembly. Nat Rev Genet 12:671–682
Meshorer E et al (2005) Chronic cholinergic imbalances promote brain diffusion and transport abnormalities. FASEB J 19:910–922
Miller JR et al (2010) Assembly algorithms for next-generation sequencing data. Genomics 95(6):315–327
Ohno S (1970) Evolution by gene duplication. Springer, Berlin/New York
Sarah BN et al (2009) Targeted capture and massively parallel sequencing of 12 human exomes. Nature 461:272–276
Schuster SC (2008) Next-generation sequencing transforms today’s biology. Nat Methods 5(1):16–18
Shannon P et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498–2504
Stoltzfus A (1999) On the possibility of constructive neutral evolution. J Mol Evol 49(2):169–181
The C. elegans Sequencing Consortium (1998) Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 282:2012–2018
Yeo G et al (2004) Variation in alternative splicing across human tissues. Genome Biol 5:R74
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Ogura, A. (2017). Genome and Transcriptome-Wide Research of Brain Evolution. In: Shigeno, S., Murakami, Y., Nomura, T. (eds) Brain Evolution by Design. Diversity and Commonality in Animals. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56469-0_8
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DOI: https://doi.org/10.1007/978-4-431-56469-0_8
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