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Effects of Organotins in Mollusk’s Lipids

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Biological Effects by Organotins

Abstract

Organotin compounds have been shown to alter lipid homeostasis and trigger adipocyte differentiation and a predisposition to obesity in vertebrates by binding to nuclear receptors (e.g., the retionid X receptor, RXR). RXR is highly conserved in evolution, and RXR homologues with high ligand affinity for tributyltin and triphenyltin have been cloned from gastropods. Thus, significant alteration of lipids as a consequence of exposure to organotin compounds is likely to occur also in mollusks. This chapter reviews the still fragmentary knowledge on the induction of lipid disturbance and membrane toxicity by organotin compounds and the potential link between those lipid alterations and the occurrence of imposex and/or altered levels of esterified steroids. Finally, the chapter emphasizes the need to characterize the richness of mollusk’s lipids (e.g., cardiolipin, plasmalogens, and many others) with the new available technologies to better understand the toxicity of organotin compounds but also other pollutants/stressors, in this very diverse animal group.

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Authors and Affiliations

  1. Environmental Chemistry Department, IDAEA –CSIC, C/ Jordi Girona 18, 08034, Barcelona, Spain

    Denise Fernandes & Cinta Porte

Authors
  1. Denise Fernandes
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  2. Cinta Porte
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Correspondence to Cinta Porte .

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Editors and Affiliations

  1. Center for Health and Environmental Risk Research, National Institute for Environmental Studies, Tsukuba, Japan

    Toshihiro Horiguchi

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Fernandes, D., Porte, C. (2017). Effects of Organotins in Mollusk’s Lipids. In: Horiguchi, T. (eds) Biological Effects by Organotins. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56451-5_10

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