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Field-Effect Transistors for Detection of Biomolecular Recognition

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Intelligent Nanosystems for Energy, Information and Biological Technologies

Abstract

Electrical biosensors have attracted increasing attention in such fields as point-of-care testing, drug discovery, and healthcare products. In order for next-generation biosensor platforms to become more useful in our daily lives, it will be necessary to significantly improve their sensitivity, specificity, and parallelism. A precisely designed thin layer in molecular dimension on a solid substrate is essential for biosensing. The surfaces of biosensors are designed to capture target bioanalytes. In addition, the solid/liquid interface plays an important role in realizing additional functionalities such as target manipulation, signal stabilization, and switching. A functional interface combined with a field-effect device would enable on-demand label-free biosensing in a portable format. In this chapter, we provide an overview of biomolecular recognition in the context of electrochemical sensing and biosensing. Also, we review recent progress and trends in biosensing, including our own research.

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Acknowledgments

Our work in this chapter was supported in part by the Japan Science and Technology Agency (JST), Core Research of Evolutional Science and Technology (CREST), and by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program),” initiated by the Council for Science and Technology Policy (CSTP).

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Authors and Affiliations

  1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-Ku, Tokyo, 101-0062, Japan

    Miyuki Tabata, Tatsuro Goda, Akira Matsumoto & Yuji Miyahara

Authors
  1. Miyuki Tabata
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  2. Tatsuro Goda
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  3. Akira Matsumoto
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  4. Yuji Miyahara
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Corresponding author

Correspondence to Yuji Miyahara .

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Editors and Affiliations

  1. Japan Science and Technology Agency, Tokyo, Japan

    Jun’ichi Sone

  2. Japan Science and Technology Agency, Tokyo, Japan

    Shinji Tsuji

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Tabata, M., Goda, T., Matsumoto, A., Miyahara, Y. (2016). Field-Effect Transistors for Detection of Biomolecular Recognition. In: Sone, J., Tsuji, S. (eds) Intelligent Nanosystems for Energy, Information and Biological Technologies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56429-4_2

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