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Bioelectrics pp 275-388 | Cite as

Medical Applications

  • Richard Heller
  • Justin Teissie
  • Marie-Pierre Rols
  • Julie Gehl
  • Gregor Sersa
  • Lluis M. Mir
  • Robert E. NealII
  • Suyashree Bhonsle
  • Rafael Davalos
  • Stephen Beebe
  • Barbara Hargrave
  • Richard Nuccitelli
  • Chunqi Jiang
  • Maja Cemazar
  • Youssef Tamzali
  • Natasa Tozon
Chapter

Abstract

Bioelectrics is a rapidly growing field at the intersection of the biological and physical sciences. Research has focused on understanding the basic interactions of pulse electric fields on biological systems, development of therapeutic and diagnostic approaches, and environmental applications. This chapter focuses on potential therapeutic and prophylactic applications of bioelectrics in human and veterinary medicine. Pulse electric fields can be ultrashort (picosecond to nanosecond) or longer (microsecond to millisecond), and dependent on the parameters of the applied pulse, the cellular effects on cells can be direct or indirect. Direct effect can include exciting cells or induction of apoptosis and/or necrosis. Indirect effects have been used to deliver molecules such as chemotherapeutics, nucleic acids, or protein into the cell interior. Therapeutic applications of bioelectrics have been developed for a large number of indications including many medical conditions including cancer, wound healing, ischemia, cardiovascular, and diabetes. The utilization of bioelectric-based medical techniques has recently surged, and the potential of such techniques has stemmed from a more wholistic understanding of the fundamental biophysical mechanisms driving underlying success.

Keywords

Electrochemotherapy Gene electrotransfer Nanosecond pulse electric fields Plasma medicine Veterinary Clinical trials Wound healing Cancer therapy 

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Copyright information

© Springer Japan 2017

Authors and Affiliations

  • Richard Heller
    • 1
  • Justin Teissie
    • 2
  • Marie-Pierre Rols
    • 2
  • Julie Gehl
    • 3
  • Gregor Sersa
    • 4
  • Lluis M. Mir
    • 5
  • Robert E. NealII
    • 6
  • Suyashree Bhonsle
    • 6
  • Rafael Davalos
    • 6
  • Stephen Beebe
    • 1
  • Barbara Hargrave
    • 1
  • Richard Nuccitelli
    • 7
  • Chunqi Jiang
    • 1
  • Maja Cemazar
    • 8
    • 9
  • Youssef Tamzali
    • 10
  • Natasa Tozon
    • 11
  1. 1.Frank Reidy Research Center for BioelectricsOld Dominion UniversityNorfolkUSA
  2. 2.Institute of Pharmacology and Structural BiologyCNRS and University of ToulouseToulouseFrance
  3. 3.Center for Experimental Drug and Gene ElectrotransferCopenhagen University HospitalHerlevDenmark
  4. 4.Department of Experimental OncologyInstitute of Oncology LjubljanaLjubljanaSlovenia
  5. 5.Laboratory of Vectorology and Anticancer TherapeuticsCNRS and University of Paris-SudVillejuifFrance
  6. 6.Bioelectromechanical Systems LaboratoryVirginia TechBlacksburgUSA
  7. 7.Pulse Biosciences, Inc.BurlingameUSA
  8. 8.Department of Experimental OncologyInstitute of Oncology LjubljanaLjubljanaSlovenia
  9. 9.Faculty of Health SciencesUniversity of PrimorskaIzolaSlovenia
  10. 10.École Nationale Vétérinaire de ToulouseToulouseFrance
  11. 11.Veterinary FacultyUniversity of LjubljanaLjubljanaSlovenia

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