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MicroRNAs in Chronic Inflammation

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Chronic Inflammation

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Abstract

MicroRNAs (miRNAs) are ~22-nucleotide single-stranded small noncoding RNAs that are highly conserved among eukaryotes. miRNAs play a central role in the posttranscriptional regulation of gene expression by inhibiting translation and/or by inducing mRNA degradation. Several recent studies have shown that miRNAs contribute to diverse physiological processes, including pathogenesis, through their role in gene suppression. In this chapter, we review the relationship between miRNAs and chronic inflammatory diseases, such as cancer and arthritis, and discuss the potential functions of miRNAs in chronic inflammation.

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Authors and Affiliations

  1. Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo, 113-8519, Japan

    Y. Ito, T. Matsushima & H. Asahara

  2. Department of Molecular and Experimental Medicine, The Scripps research Institute, San Diego, CA, 92131, USA

    S. Mokuda, K. Miyata & H. Asahara

  3. AMED-CREST, Tokyo, 113-8519, Japan

    H. Asahara

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  1. Y. Ito
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  2. S. Mokuda
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  3. K. Miyata
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  4. T. Matsushima
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  5. H. Asahara
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Correspondence to H. Asahara .

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Editors and Affiliations

  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Ito, Y., Mokuda, S., Miyata, K., Matsushima, T., Asahara, H. (2016). MicroRNAs in Chronic Inflammation. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_4

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