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The Multifaceted Role of PD-1 in Health and Disease

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Chronic Inflammation

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Abstract

Properly functioning T cells should clear invading pathogens and tumors without causing damage to the host. Programmed cell death-1 (PD-1) is a negative costimulatory receptor that is expressed on an effector T cell to regulate its functions; otherwise, uncontrolled activation of T cells might cause collateral tissue damage and autoimmune diseases. However, such a beneficial regulatory tool has been hijacked by several pathogens and tumors to promote chronic infection and evade antitumor immunity, respectively. PD-1 ligands are expressed by a variety of haematopoietic and non-haematopoietic cells all over the body under steady state and their expression is further modulated within different pathological conditions, suggesting that PD-1 is an immune checkpoint that is utilised by the body to regulate T-cell functions in different contexts. Furthermore, blocking PD-1 has recently received attention as a promising therapeutic approach for the treatment of cancer and chronic viral infections. Herein, we shed some light on the current knowledge of PD-1 biology and role in its health and disease.

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Authors and Affiliations

  1. Laboratory for Cell Signaling, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Kanagawa, 230-0045, Japan

    Mohamed El Sherif Gadelhaq Badr

  2. WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, 565-0871, Japan

    Mohamed El Sherif Gadelhaq Badr

  3. Department of Immunology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Kikumi Hata, Masae Furuhata, Hiroko Toyota & Tadashi Yokosuka

  4. PRESTO, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan

    Tadashi Yokosuka

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  1. Mohamed El Sherif Gadelhaq Badr
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  2. Kikumi Hata
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  3. Masae Furuhata
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  5. Tadashi Yokosuka
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Correspondence to Tadashi Yokosuka .

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  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Badr, M.E.S.G., Hata, K., Furuhata, M., Toyota, H., Yokosuka, T. (2016). The Multifaceted Role of PD-1 in Health and Disease. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_34

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