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Chronic Inflammation pp 333–344Cite as

Roles of C-Type Lectin Receptors in Inflammatory Responses

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Abstract

Myeloid cells act central roles in inflammatory responses. C-type lectin receptors (CLRs) are key players that are expressed mainly in these cells to orchestrate immune responses for maintaining immune homeostasis. These receptors recognise carbohydrate structures in microbes, including fungi, bacteria, viruses, and parasites, as pathogen-associated molecular patterns (PAMPs); some of the receptors recognise self-ligands and some recognise both. Ligand ligations of these receptors initiate various biological reactions such as proinflammatory, anti-inflammatory, endocytic, or phagocytic responses. Owing to these activities, the pleiotropic roles of CLRs have an important effect on homeostasis in the body. In addition, because of these varied abilities, it is thought that inhibitors or activators of this receptor signalling are good therapeutic agents for inflammatory disorders. In this section, we provide a detailed summary of the current knowledge of these receptors, describing their expression, ligand recognition, signalling, and associated diseases, and how they function in innate and adaptive immunity.

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Authors and Affiliations

  1. Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chiba, Japan, 260-8673

    Shinobu Saijo

  2. PRESTO, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan

    Shinobu Saijo

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  1. Shinobu Saijo
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Correspondence to Shinobu Saijo .

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Editors and Affiliations

  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Saijo, S. (2016). Roles of C-Type Lectin Receptors in Inflammatory Responses. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_26

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