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Functional Bio-imaging

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Cell Therapy Against Cerebral Stroke

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Abstract

Cell transplantation therapy has been expected to promote functional recovery in various kinds of central nervous system (CNS) disorders, including cerebral stroke. However, there are several concerns to be resolved before clinical application of cell therapy for CNS disorders. The issues include the development of imaging techniques to monitor the response of the host CNS. It would be essential to establish functional bio-imaging technique serially and noninvasively validating the effects of cell therapy on the host CNS in order to achieve clinical application of cell therapy for cerebral stroke. Nuclear imaging technique is one of the most useful methods to assess the functional change in various kinds of CNS disorders, including cerebral stroke. Very recently, using a small-animal SPECT/CT apparatus, we could serially visualize the effects of BMSC transplantation on the distribution of 123I-IMZ in the infarct brain of the living rodents longitudinally and noninvasively. Furthermore, we serially assessed local glucose metabolism in the rats subjected to permanent MCA occlusion and found that BMSC transplantation significantly enhances the recovery in the peri-infarct area, using small-animal 18F-FDG PET/CT system. The BMSCs may enhance the recovery of local glucose metabolism by improving neuronal integrity in the peri-infarct area, when directly transplanted into the infarct brain. Although there are few studies that indicate the utility of imaging techniques to monitor the response of the host CNS after cell therapy and further investigation is needed, 123I-IMZ SPECT and 18F-FDG PET may be promising modalities to assess the therapeutic benefits of cell therapy for ischemic stroke without subjective bias in clinical situation.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Japanese Red Cross Asahikawa Hospital, 1-1-1-1, Akebono, Asahikawa, Hokkaido, 070-8530, Japan

    Hisayasu Saito

  2. Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan

    Hisayasu Saito, Michiyuki Miyamoto, Hideo Shichinohe & Kiyohiro Houkin

  3. Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Satoshi Kuroda

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  1. Hisayasu Saito
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  2. Michiyuki Miyamoto
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  3. Hideo Shichinohe
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  4. Kiyohiro Houkin
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  5. Satoshi Kuroda
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Correspondence to Hisayasu Saito .

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Editors and Affiliations

  1. Hokkaido University Graduate School of M, Department of Neurosurgery, Sapporo, Hokkaido, Japan

    Kiyohiro Houkin

  2. Okayama University Graduate School of Me, Department of Neurology, Okayama, Okayama, Japan

    Koji Abe

  3. Graduate School of Medicine and Pharmace, Department of Neurosurgery, Toyama, Toyama, Japan

    Satoshi Kuroda

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Saito, H., Miyamoto, M., Shichinohe, H., Houkin, K., Kuroda, S. (2017). Functional Bio-imaging. In: Houkin, K., Abe, K., Kuroda, S. (eds) Cell Therapy Against Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56059-3_9

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  • DOI: https://doi.org/10.1007/978-4-431-56059-3_9

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