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Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients

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Cell Therapy Against Cerebral Stroke

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Abstract

Therapeutic angiogenesis mediated by hematopoietic stem cell transplantation has been initiated in patients with ischemic diseases and has shown promising results. We previously demonstrated that therapeutic angiogenesis is essential for neurogenesis after stroke and that intravenous administration of hematopoietic stem cells improves functional recovery through enhanced angiogenesis in an experimental stroke model. Based on these observations, we initiated a clinical trial of cell therapies with the aim of achieving functional recovery in patients with cerebral ischemia through regenerative microcirculation in the brain following a stroke.

This review summarizes recent findings from basic and clinical research on stroke and introduces our own clinical trial aimed at enhancing functional recovery in stroke patients using bone marrow mononuclear cells.

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Authors and Affiliations

  1. Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan

    Yukiko Kasahara & Akihiko Taguchi

  2. Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo, Japan, 663-8501

    Tomohiro Matsuyama

Authors
  1. Yukiko Kasahara
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  2. Tomohiro Matsuyama
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  3. Akihiko Taguchi
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Correspondence to Akihiko Taguchi .

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Editors and Affiliations

  1. Hokkaido University Graduate School of M, Department of Neurosurgery, Sapporo, Hokkaido, Japan

    Kiyohiro Houkin

  2. Okayama University Graduate School of Me, Department of Neurology, Okayama, Okayama, Japan

    Koji Abe

  3. Graduate School of Medicine and Pharmace, Department of Neurosurgery, Toyama, Toyama, Japan

    Satoshi Kuroda

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Kasahara, Y., Matsuyama, T., Taguchi, A. (2017). Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke Patients. In: Houkin, K., Abe, K., Kuroda, S. (eds) Cell Therapy Against Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56059-3_11

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