Abstract
Dendrites exhibit a diverse array of complex but often stereotyped morphologies that influence the inputs a neuron can receive and how these inputs are processed. While dendrite morphology is a hallmark of neuronal type, with neurons of a given type elaborating type-specific dendrite arbors, certain organizing principles govern patterning and spacing of dendrite and axon arbors. In many cases, particularly in sensory systems, dendrites of same-type neurons are arranged in ordered mosaics. In some of these mosaics, neurites of a single functional class of neurons are arranged to allow complete and nonredundant representation of territory – a phenomenon referred to as tiling. Tiling dendrites (and axons) minimally overlap with dendrites of the same functional class, but freely overlap with dendrites of different neurons, therefore tiling dendrites must be able to recognize and avoid “self”-dendrites while coexisting with “nonself”-dendrites. Tiled mosaics have been observed in non-neuronal cells as well, suggesting that tiling is a general mechanism for cell spacing. Here I will provide an overview of the cellular mechanism of tiling in neurons, with a focus on studies in model systems that have provided information about signaling systems underlying the establishment and maintenance of tiled mosaics.
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Albeg A, Smith CJ, Chatzigeorgiou M, Feitelson DG, Hall DH, Schafer WR, Miller DM, Treinin M (2011) C. elegans multi-dendritic sensory neurons: morphology and function. Mol Cell Neurosci 46:308–317. doi:10.1016/j.mcn.2010.10.001
Amthor FR, Oyster CW (1995) Spatial organization of retinal information about the direction of image motion. Proc Natl Acad Sci U S A 92:4002–4005
Ashley JA, Katz FN (1994) Competition and position-dependent targeting in the development of the Drosophila R7 visual projections. Dev Camb Engl 120:1537–1547
Ault SJ, Leventhal AG (1994) Postnatal development of different classes of cat retinal ganglion cells. J Comp Neurol 339:106–116. doi:10.1002/cne.903390110
Bentley D, Toroian-Raymond A (1981) Embryonic and postembryonic morphogenesis of a grasshopper interneuron. J Comp Neurol 201:507–518. doi:10.1002/cne.902010404
Blackshaw SE (1981) Morphology and distribution of touch cell terminals in the skin of the leech. J Physiol 320:219–228
Blackshaw SE, Nicholls JG, Parnas I (1982) Expanded receptive fields of cutaneous mechanoreceptor cells after single neurone deletion in leech central nervous system. J Physiol 326:261–268
Bloomfield SA, Hitchcock PF (1991) Dendritic arbors of large-field ganglion cells show scaled growth during expansion of the goldfish retina: a study of morphometric and electrotonic properties. J Neurosci Off J Soc Neurosci 11:910–917
Bucher, Pflüger (2000) Directional sensitivity of an identified wind-sensitive interneuron during the postembryonic development of the locust. J Insect Physiol 46:1545–1556
Bushong EA, Martone ME, Jones YZ, Ellisman MH (2002) Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci Off J Soc Neurosci 22:183–192
Cameron S, Rao Y (2010) Molecular mechanisms of tiling and self-avoidance in neural development. Mol Brain 3:28. doi:10.1186/1756-6606-3-28
Cameron S, Chang W-T, Chen Y, Zhou Y, Taran S, Rao Y (2013) Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein borderless. J Neurosci Off J Soc Neurosci 33:17413–17421. doi:10.1523/JNEUROSCI.1878-13.2013
Cook JE (1996) Spatial properties of retinal mosaics: an empirical evaluation of some existing measures. Vis Neurosci 13:15–30
Dacey DM (1993) The mosaic of midget ganglion cells in the human retina. J Neurosci Off J Soc Neurosci 13:5334–5355
Dann JF, Buhl EH, Peichl L (1988) Postnatal dendritic maturation of alpha and beta ganglion cells in cat retina. J Neurosci Off J Soc Neurosci 8:1485–1499
Devries SH, Baylor DA (1997) Mosaic arrangement of ganglion cell receptive fields in rabbit retina. J Neurophysiol 78:2048–2060
Dong X, Liu OW, Howell AS, Shen K (2013) An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis. Cell 155:296–307. doi:10.1016/j.cell.2013.08.059
Emoto K, He Y, Ye B, Grueber WB, Adler PN, Jan LY, Jan Y-N (2004) Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119:245–256. doi:10.1016/j.cell.2004.09.036
Emoto K, Parrish JZ, Jan LY, Jan Y-N (2006) The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 443:210–213. doi:10.1038/nature05090
Eysel UT, Peichl L, Wässle H (1985) Dendritic plasticity in the early postnatal feline retina: quantitative characteristics and sensitive period. J Comp Neurol 242:134–145. doi:10.1002/cne.902420109
Ferguson K, Long H, Cameron S, Chang W-T, Rao Y (2009) The conserved Ig superfamily member turtle mediates axonal tiling in Drosophila. J Neurosci Off J Soc Neurosci 29:14151–14159. doi:10.1523/JNEUROSCI.2497-09.2009
Frank E, Westerfield M (1982) The formation of appropriate central and peripheral connexions by foreign sensory neurones of the bullfrog. J Physiol 324:495–505
Fujishima K, Horie R, Mochizuki A, Kengaku M (2012) Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites. Dev Camb Engl 139:3442–3455. doi:10.1242/dev.081315
Gallegos ME, Bargmann CI (2004) Mechanosensory neurite termination and tiling depend on SAX-2 and the SAX-1 kinase. Neuron 44:239–249. doi:10.1016/j.neuron.2004.09.021
Galli-Resta L, Resta G, Tan SS, Reese BE (1997) Mosaics of islet-1-expressing amacrine cells assembled by short-range cellular interactions. J Neurosci Off J Soc Neurosci 17:7831–7838
Gandarillas A, Freije A (2014) Cycling up the epidermis: reconciling 100 years of debate. Exp Dermatol 23:87–91. doi:10.1111/exd.12287
Gao FB, Kohwi M, Brenman JE, Jan LY, Jan YN (2000) Control of dendritic field formation in Drosophila: the roles of flamingo and competition between homologous neurons. Neuron 28:91–101
Gershon TR, Baker MW, Nitabach M, Macagno ER (1998) The leech receptor protein tyrosine phosphatase HmLAR2 is concentrated in growth cones and is involved in process outgrowth. Dev Camb Engl 125:1183–1190
Gibson DA, Tymanskyj S, Yuan RC, Leung HC, Lefebvre JL, Sanes JR, Chédotal A, Ma L (2014) Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells. Neuron 81:1040–1056. doi:10.1016/j.neuron.2014.01.009
Grueber WB, Sagasti A (2010) Self-avoidance and tiling: mechanisms of dendrite and axon spacing. Cold Spring Harb Perspect Biol. doi:10.1101/cshperspect.a001750
Grueber WB, Graubard K, Truman JW (2001) Tiling of the body wall by multidendritic sensory neurons in Manduca sexta. J Comp Neurol 440:271–283. doi:10.1002/cne.1385
Grueber WB, Jan LY, Jan YN (2002) Tiling of the Drosophila epidermis by multidendritic sensory neurons. Dev Camb Engl 129:2867–2878
Grueber WB, Ye B, Moore AW, Jan LY, Jan YN (2003) Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr Biol CB 13:618–626
Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY, Jan Y-N (2012a) Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron 73:64–78. doi:10.1016/j.neuron.2011.10.036
Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY, Jan Y-N (2012b) Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron 73:64–78. doi:10.1016/j.neuron.2011.10.036
Hattori D, Millard SS, Wojtowicz WM, Zipursky SL (2008) Dscam-mediated cell recognition regulates neural circuit formation. Annu Rev Cell Dev Biol 24:597–620. doi:10.1146/annurev.cellbio.24.110707.175250
Hayes BP, Roberts A (1983) The anatomy of two functional types of mechanoreceptive “free” nerve-ending in the head skin of Xenopus embryos. Proc R Soc Lond B Biol Sci 218:61–76
Hedgecock EM, White JG (1985) Polyploid tissues in the nematode Caenorhabditis elegans. Dev Biol 107:128–133
Hergovich A, Bichsel SJ, Hemmings BA (2005) Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation. Mol Cell Biol 25:8259–8272. doi:10.1128/MCB.25.18.8259-8272.2005
Hergovich A, Stegert MR, Schmitz D, Hemmings BA (2006) NDR kinases regulate essential cell processes from yeast to humans. Nat Rev Mol Cell Biol 7:253–264. doi:10.1038/nrm1891
Hitchcock PF (1987) Constant dendritic coverage by ganglion cells with growth of the goldfish’s retina. Vision Res 27:17–22
Hitchcock PF (1989) Exclusionary dendritic interactions in the retina of the goldfish. Dev Camb Engl 106:589–598
Hitchcock PF, Easter SS (1986) Retinal ganglion cells in goldfish: a qualitative classification into four morphological types, and a quantitative study of the development of one of them. J Neurosci Off J Soc Neurosci 6:1037–1050
Huckfeldt RM, Schubert T, Morgan JL, Godinho L, Di Cristo G, Huang ZJ, Wong ROL (2009) Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions. Nat Neurosci 12:35–43. doi:10.1038/nn.2236
Hughes ME, Bortnick R, Tsubouchi A, Bäumer P, Kondo M, Uemura T, Schmucker D (2007) Homophilic Dscam interactions control complex dendrite morphogenesis. Neuron 54:417–427. doi:10.1016/j.neuron.2007.04.013
Jiang N, Soba P, Parker E, Kim CC, Parrish JZ (2014) The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth. Dev Camb Engl 141:2657–2668. doi:10.1242/dev.107573
Kay JN, Chu MW, Sanes JR (2012) MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature 483:465–469. doi:10.1038/nature10877
Keeley PW, Reese BE (2010) Morphology of dopaminergic amacrine cells in the mouse retina: independence from homotypic interactions. J Comp Neurol 518:1220–1231. doi:10.1002/cne.22270
Keeley PW, Whitney IE, Raven MA, Reese BE (2007) Dendritic spread and functional coverage of starburst amacrine cells. J Comp Neurol 505:539–546. doi:10.1002/cne.21518
Kim ME, Shrestha BR, Blazeski R, Mason CA, Grueber WB (2012) Integrins establish dendrite-substrate relationships that promote dendritic self-avoidance and patterning in drosophila sensory neurons. Neuron 73:79–91. doi:10.1016/j.neuron.2011.10.033
Kitson DL, Roberts A (1983) Competition during innervation of embryonic amphibian head skin. Proc R Soc Lond B Biol Sci 218:49–59
Kniss JS, Holbrook S, Herman TG (2013) R7 photoreceptor axon growth is temporally controlled by the transcription factor Ttk69, which inhibits growth in part by promoting transforming growth factor-β/activin signaling. J Neurosci Off J Soc Neurosci 33:1509–1520. doi:10.1523/JNEUROSCI.2023-12.2013
Kock JH (1982) Dendritic tree structure and dendritic hypertrophy during growth of the crucian carp eye. J Comp Neurol 209:275–286. doi:10.1002/cne.902090306
Koike-Kumagai M, Yasunaga K, Morikawa R, Kanamori T, Emoto K (2009) The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J 28:3879–3892. doi:10.1038/emboj.2009.312
Koleske AJ (2013) Molecular mechanisms of dendrite stability. Nat Rev Neurosci 14:536–550. doi:10.1038/nrn3486
Kramer AP, Kuwada JY (1983) Formation of the receptive fields of leech mechanosensory neurons during embryonic development. J Neurosci Off J Soc Neurosci 3:2474–2486
Kramer AP, Stent GS (1985) Developmental arborization of sensory neurons in the leech Haementeria ghilianii. II. Experimentally induced variations in the branching pattern. J Neurosci Off J Soc Neurosci 5:768–775
Lah GJ-E, Li JSS, Millard SS (2014) Cell-specific alternative splicing of Drosophila Dscam2 is crucial for proper neuronal wiring. Neuron 83:1376–1388. doi:10.1016/j.neuron.2014.08.002
Lee SCS, Cowgill EJ, Al-Nabulsi A, Quinn EJ, Evans SM, Reese BE (2011) Homotypic regulation of neuronal morphology and connectivity in the mouse retina. J Neurosci Off J Soc Neurosci 31:14126–14133. doi:10.1523/JNEUROSCI.2844-11.2011
Lee J, Peng Y, Lin W-Y, Parrish JZ (2015) Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw. Dev Camb Engl 142:162–173. doi:10.1242/dev.113423
Lefebvre JL, Kostadinov D, Chen WV, Maniatis T, Sanes JR (2012) Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. Nature 488:517–521. doi:10.1038/nature11305
Leventhal AG, Schall JD, Ault SJ (1988) Extrinsic determinants of retinal ganglion cell structure in the cat. J Neurosci Off J Soc Neurosci 8:2028–2038
Leventhal AG, Ault SJ, Vitek DJ, Shou T (1989) Extrinsic determinants of retinal ganglion cell development in primates. J Comp Neurol 286:170–189. doi:10.1002/cne.902860204
Liang X, Dong X, Moerman DG, Shen K, Wang X (2015) Sarcomeres pattern proprioceptive sensory dendritic endings through UNC-52/Perlecan in C. elegans. Dev Cell 33:388–400. doi:10.1016/j.devcel.2015.03.010
Lin B, Wang SW, Masland RH (2004) Retinal ganglion cell type, size, and spacing can be specified independent of homotypic dendritic contacts. Neuron 43:475–485. doi:10.1016/j.neuron.2004.08.002
Lozano E, Sáez AG, Flemming AJ, Cunha A, Leroi AM (2006) Regulation of growth by ploidy in Caenorhabditis elegans. Curr Biol CB 16:493–498. doi:10.1016/j.cub.2006.01.048
Masland RH (2012) The neuronal organization of the retina. Neuron 76:266–280. doi:10.1016/j.neuron.2012.10.002
Matthews BJ, Kim ME, Flanagan JJ, Hattori D, Clemens JC, Zipursky SL, Grueber WB (2007) Dendrite self-avoidance is controlled by Dscam. Cell 129:593–604. doi:10.1016/j.cell.2007.04.013
Millard SS, Zipursky SL (2008) Dscam-mediated repulsion controls tiling and self-avoidance. Curr Opin Neurobiol 18:84–89. doi:10.1016/j.conb.2008.05.005
Millard SS, Flanagan JJ, Pappu KS, Wu W, Zipursky SL (2007) Dscam2 mediates axonal tiling in the Drosophila visual system. Nature 447:720–724. doi:10.1038/nature05855
Mizumoto K, Shen K (2013) Interaxonal interaction defines tiled presynaptic innervation in C. elegans. Neuron 77:655–666. doi:10.1016/j.neuron.2012.12.031
Montague PR, Friedlander MJ (1991) Morphogenesis and territorial coverage by isolated mammalian retinal ganglion cells. J Neurosci Off J Soc Neurosci 11:1440–1457
Negishi K, Teranishi T, Kato S (1982) New dopaminergic and indoleamine-accumulating cells in the growth zone of goldfish retinas after neurotoxic destruction. Science 216:747–749
Nern A, Pfeiffer BD, Rubin GM (2015) Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1506763112
Nicholls JG, Baylor DA (1968) Specific modalities and receptive fields of sensory neurons in CNS of the leech. J Neurophysiol 31:740–756
O’Brien GS, Martin SM, Söllner C, Wright GJ, Becker CG, Portera-Cailliau C, Sagasti A (2009) Developmentally regulated impediments to skin reinnervation by injured peripheral sensory axon terminals. Curr Biol CB 19:2086–2090. doi:10.1016/j.cub.2009.10.051
O’Brien GS, Rieger S, Wang F, Smolen GA, Gonzalez RE, Buchanan J, Sagasti A (2012) Coordinate development of skin cells and cutaneous sensory axons in zebrafish. J Comp Neurol 520:816–831. doi:10.1002/cne.22791
Ogata K, Kosaka T (2002) Structural and quantitative analysis of astrocytes in the mouse hippocampus. Neuroscience 113:221–233
Orr-Weaver TL (2015) When bigger is better: the role of polyploidy in organogenesis. Trends Genet TIG. doi:10.1016/j.tig.2015.03.011
Parrish JZ, Emoto K, Jan LY, Jan YN (2007) Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev 21:956–972. doi:10.1101/gad.1514507
Parrish JZ, Xu P, Kim CC, Jan LY, Jan YN (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63:788–802. doi:10.1016/j.neuron.2009.08.006
Perry VH, Linden R (1982) Evidence for dendritic competition in the developing retina. Nature 297:683–685
Ramoa AS, Campbell G, Shatz CJ (1987) Transient morphological features of identified ganglion cells in living fetal and neonatal retina. Science 237:522–525
Ramoa AS, Campbell G, Shatz CJ (1988) Dendritic growth and remodeling of cat retinal ganglion cells during fetal and postnatal development. J Neurosci Off J Soc Neurosci 8:4239–4261
Raven MA, Stagg SB, Nassar H, Reese BE (2005) Developmental improvement in the regularity and packing of mouse horizontal cells: implications for mechanisms underlying mosaic pattern formation. Vis Neurosci 22:569–573. doi:10.1017/S095252380522504X
Reese BE, Keeley PW (2014) Design principles and developmental mechanisms underlying retinal mosaics. Biol Rev Camb Philos Soc. doi:10.1111/brv.12139
Reese BE, Raven MA, Stagg SB (2005) Afferents and homotypic neighbors regulate horizontal cell morphology, connectivity, and retinal coverage. J Neurosci Off J Soc Neurosci 25:2167–2175. doi:10.1523/JNEUROSCI.4876-04.2005
Reese BE, Keeley PW, Lee SCS, Whitney IE (2011) Developmental plasticity of dendritic morphology and the establishment of coverage and connectivity in the outer retina. Dev Neurobiol 71:477–490. doi:10.1002/dneu.20903
Rehberg K, Kliche S, Madencioglu DA, Thiere M, Müller B, Meineke BM, Freund C, Budinger E, Stork O (2014) The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. J Neurosci Off J Soc Neurosci 34:5342–5354. doi:10.1523/JNEUROSCI.2728-13.2014
Ren L, Liang H, Diao L, He S (2010) Changing dendritic field size of mouse retinal ganglion cells in early postnatal development. Dev Neurobiol 70:397–407. doi:10.1002/dneu.20777
Rockhill RL, Euler T, Masland RH (2000) Spatial order within but not between types of retinal neurons. Proc Natl Acad Sci U S A 97:2303–2307. doi:10.1073/pnas.030413497
Rockhill RL, Daly FJ, MacNeil MA, Brown SP, Masland RH, (2002) The diversity of ganglion cells in a mammalian retina. J Neurosci Off J Soc Neurosci 22:3831–3843
Sagasti A, Guido MR, Raible DW, Schier AF (2005) Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors. Curr Biol CB 15:804–814. doi:10.1016/j.cub.2005.03.048
Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z, Bülow HE (2013) Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Cell 155:308–320. doi:10.1016/j.cell.2013.08.058
Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL (2000) Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101:671–684
Scott SA, Cooper E, Diamond J (1981) Merkel cells as targets of the mechanosensory nerves in salamander skin. Proc R Soc Lond B Biol Sci 211:455–470
Shimono K, Fujimoto A, Tsuyama T, Yamamoto-Kochi M, Sato M, Hattori Y, Sugimura K, Usui T, Kimura K, Uemura T (2009) Multidendritic sensory neurons in the adult Drosophila abdomen: origins, dendritic morphology, and segment- and age-dependent programmed cell death. Neural Dev 4:37. doi:10.1186/1749-8104-4-37
Shimono K, Fujishima K, Nomura T, Ohashi M, Usui T, Kengaku M, Toyoda A, Uemura T (2014) An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. Sci Rep 4:4415. doi:10.1038/srep04415
Smith CJ, Watson JD, Spencer WC, O’Brien T, Cha B, Albeg A, Treinin M, Miller DM (2010) Time-lapse imaging and cell-specific expression profiling reveal dynamic branching and molecular determinants of a multi-dendritic nociceptor in C. elegans. Dev Biol 345:18–33. doi:10.1016/j.ydbio.2010.05.502
Smith CJ, O’Brien T, Chatzigeorgiou M, Spencer WC, Feingold-Link E, Husson SJ, Hori S, Mitani S, Gottschalk A, Schafer WR, Miller DM (2013) Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization. Neuron 79:266–280. doi:10.1016/j.neuron.2013.05.009
Soba P, Zhu S, Emoto K, Younger S, Yang S-J, Yu H-H, Lee T, Jan LY, Jan Y-N (2007) Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron 54:403–416. doi:10.1016/j.neuron.2007.03.029
Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YN (2015) The ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion. eLife 4:e05491. doi:10.7554/eLife.05491
Sugimura K, Yamamoto M, Niwa R, Satoh D, Goto S, Taniguchi M, Hayashi S, Uemura T (2003) Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons. J Neurosci Off J Soc Neurosci 23:3752–3760
Sulkowski MJ, Iyer SC, Kurosawa MS, Iyer EPR, Cox DN (2011) Turtle functions downstream of cut in differentially regulating class specific dendrite morphogenesis in Drosophila. PLoS One 6:e22611. doi:10.1371/journal.pone.0022611
Tauchi M, Masland RH (1984) The shape and arrangement of the cholinergic neurons in the rabbit retina. Proc R Soc Lond B Biol Sci 223:101–119
Tauchi M, Masland RH (1985) Local order among the dendrites of an amacrine cell population. J Neurosci Off J Soc Neurosci 5:2494–2501
Ting C-Y, Herman T, Yonekura S, Gao S, Wang J, Serpe M, O’Connor MB, Zipursky SL, Lee C-H (2007) Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron 56:793–806. doi:10.1016/j.neuron.2007.09.033
Ting C-Y, McQueen PG, Pandya N, Lin T-Y, Yang M, Reddy OV, O’Connor MB, McAuliffe M, Lee C-H (2014) Photoreceptor-derived activin promotes dendritic termination and restricts the receptive fields of first-order interneurons in Drosophila. Neuron 81:830–846. doi:10.1016/j.neuron.2013.12.012
Truman JW, Reiss SE (1988) Hormonal regulation of the shape of identified motoneurons in the moth Manduca sexta. J Neurosci Off J Soc Neurosci 8:765–775
Unhavaithaya Y, Orr-Weaver TL (2012) Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity. Genes Dev 26:31–36. doi:10.1101/gad.177436.111
Vaney DI (1984) “Coronate” amacrine cells in the rabbit retina have the “starburst” dendritic morphology. Proc R Soc Lond B Biol Sci 220:501–508
Vonhoff F, Duch C (2010) Tiling among stereotyped dendritic branches in an identified Drosophila motoneuron. J Comp Neurol 518:2169–2185. doi:10.1002/cne.22380
Wang F, Wolfson SN, Gharib A, Sagasti A (2012) LAR receptor tyrosine phosphatases and HSPGs guide peripheral sensory axons to the skin. Curr Biol CB 22:373–382. doi:10.1016/j.cub.2012.01.040
Wässle H, Riemann HJ (1978) The mosaic of nerve cells in the mammalian retina. Proc R Soc Lond B Contain Pap Biol Charact R Soc G B 200:441–461
Wässle H, Peichl L, Boycott BB (1981) Dendritic territories of cat retinal ganglion cells. Nature 292:344–345
Wässle H, Puller C, Müller F, Haverkamp S (2009) Cone contacts, mosaics, and territories of bipolar cells in the mouse retina. J Neurosci Off J Soc Neurosci 29:106–117. doi:10.1523/JNEUROSCI.4442-08.2009
Yasunaga K, Kanamori T, Morikawa R, Suzuki E, Emoto K (2010) Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase-mediated modification of the basement membranes. Dev Cell 18:621–632. doi:10.1016/j.devcel.2010.02.010
Zanet J, Freije A, Ruiz M, Coulon V, Sanz JR, Chiesa J, Gandarillas A (2010) A mitosis block links active cell cycle with human epidermal differentiation and results in endoreplication. PLoS One 5:e15701. doi:10.1371/journal.pone.0015701
Acknowledgments
I would like to thank Akira Chiba, Nan Jiang, Wen-Yang Lin, David Miller, Alvaro Sagasti, and Rachel Wong for contributing unpublished images. Thanks also to Peter Soba and Michael Kim for helpful discussions. This work was supported by National Institutes of Health grant NINDS R01-NS076614.
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Parrish, J.Z. (2016). Tiling and Mosaic Spacing of Dendrites. In: Emoto, K., Wong, R., Huang, E., Hoogenraad, C. (eds) Dendrites. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56050-0_9
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