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Modifying Dendritic Structure After Function

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Dendrites

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Abstract

Neurons develop highly specialized dendritic architecture for certain operations of information processing in the brain. In this chapter, we review the development and regulation of characterized patterns of dendritic morphology and arrangement of bipolar neurons in the auditory brainstem, an excellent example of highly specialized dendritic architecture for their function in temporal coding and coincidence detection. We describe dramatic dynamics of the dendrites in both developing and mature systems and discuss the role of afferent synaptic input in influencing both the size of dendritic tree and the pattern of dendritic arborizations. The unique dendritic structure of these neurons provides an advantageous model for further understanding of the specific roles of neurotransmission, calcium signaling, protein synthesis, and cytoskeletal regulation in this important form of brain dynamics. Importantly, these neurons are highly conserved structurally and functionally across vertebrates including humans, emphasizing stereotyped dendritic regulation that is evolutionarily conserved for fundamental information processing operations in the vertebrate brain.

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Acknowledgments

Sponsored by National Institute on Deafness and Other Communication Disorders grants DC-013074, DC-03829, DC-02739, DC-04661, and DC-00018.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, 32306, USA

    Yuan Wang

  2. Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Box 357923, Seattle, WA, 98195, USA

    Edwin W. Rubel

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  1. Yuan Wang
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Correspondence to Edwin W. Rubel .

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Editors and Affiliations

  1. Graduate School of Science, The University of Tokyo, Tokyo, Japan

    Kazuo Emoto

  2. Department of Biological Structure, University of Washington, Seattle, Washington, USA

    Rachel Wong

  3. Department of Pathology, University of California San Francisco, San Francisco, California, USA

    Eric Huang

  4. Faculty of Science, Utrecht University, Utrecht, The Netherlands

    Casper Hoogenraad

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Wang, Y., Rubel, E.W. (2016). Modifying Dendritic Structure After Function. In: Emoto, K., Wong, R., Huang, E., Hoogenraad, C. (eds) Dendrites. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56050-0_11

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