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Histopathological Characteristics of Noncardiac Organs in Kawasaki Disease

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Kawasaki Disease

Abstract

Kawasaki disease (KD) causes inflammation in medium-sized muscular arteries throughout the body, including the coronary artery, and is thus classified as a systemic vasculitis syndrome. In this chapter we review the histopathology of noncardiac organs, with a focus on vascular lesions. The main histopathological characteristic of KD vasculitis is proliferative inflammation consisting of marked accumulation of monocytes/macrophages. Vasculitis throughout the body starts at disease onset, rapidly reaches an inflammatory peak, and then slowly subsides and heals with scarring. KD vasculitis is thus a monophasic inflammatory process.

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Authors and Affiliations

  1. Department of Pathology, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro, Tokyo, 153-8515, Japan

    Kei Takahashi, Toshiaki Oharaseki, Yuki Yokouchi & Yoshinori Enomoto

Authors
  1. Kei Takahashi
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  2. Toshiaki Oharaseki
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  3. Yuki Yokouchi
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  4. Yoshinori Enomoto
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Corresponding author

Correspondence to Kei Takahashi .

Editor information

Editors and Affiliations

  1. Advanced and Integrated Cardiovascular Research Course in the Young and Adolescence, Toho University, Tokyo, Japan

    Ben Tsutomu Saji

  2. Boston Children’s Hospital, Harvard Medical School, Department of Cardiology, Boston, Massachusetts, USA

    Jane W. Newburger

  3. Department of Pediatrics, Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, USA

    Jane C. Burns

  4. Heart Center , Seattle Childrens Hospital, Seattle, USA

    Masato Takahashi

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Takahashi, K., Oharaseki, T., Yokouchi, Y., Enomoto, Y. (2017). Histopathological Characteristics of Noncardiac Organs in Kawasaki Disease. In: Saji, B., Newburger, J., Burns, J., Takahashi, M. (eds) Kawasaki Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56039-5_3

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  • DOI: https://doi.org/10.1007/978-4-431-56039-5_3

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-56037-1

  • Online ISBN: 978-4-431-56039-5

  • eBook Packages: MedicineMedicine (R0)

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