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Kawasaki Disease pp 11–16Cite as

Histopathology of Coronary Arteritis in Acute Kawasaki Disease and Murine Systemic Vasculitis Induced by Candida Albicans Cell Wall Polysaccharide

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Abstract

This chapter describes the characteristics of Kawasaki disease vasculitis and a Candida albicans cell wall polysaccharide–induced murine vasculitis model. Kawasaki disease vasculitis and murine vasculitis have a number of similarities, namely, (1) vasculitis readily develops at bifurcations of medium-sized arteries, (2) inflammatory cell infiltrate mainly comprises neutrophils and macrophages; fibrinoid necrosis is rare, (3) vasculitis follows the typical course of acute inflammation, (4) proinflammatory cytokines such as tumor necrosis factor α are closely associated with vasculitis onset, and (5) vasculitis shows some response to IVIG therapy and anti–tumor necrosis factor α therapy.

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Authors and Affiliations

  1. Department of Pathology, Toho University Ohashi Medical Center, 2-17-6, Ohashi, Meguro-ku, Tokyo, 153-8515, Japan

    Toshiaki Oharaseki, Yuki Yokouchi, Yasunori Enomoto & Kei Takahashi

Authors
  1. Toshiaki Oharaseki
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  2. Yuki Yokouchi
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  3. Yasunori Enomoto
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  4. Kei Takahashi
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Corresponding author

Correspondence to Toshiaki Oharaseki .

Editor information

Editors and Affiliations

  1. Advanced and Integrated Cardiovascular Research Course in the Young and Adolescence, Toho University, Tokyo, Japan

    Ben Tsutomu Saji

  2. Boston Children’s Hospital, Harvard Medical School, Department of Cardiology, Boston, Massachusetts, USA

    Jane W. Newburger

  3. Department of Pediatrics, Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, USA

    Jane C. Burns

  4. Heart Center , Seattle Childrens Hospital, Seattle, USA

    Masato Takahashi

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Oharaseki, T., Yokouchi, Y., Enomoto, Y., Takahashi, K. (2017). Histopathology of Coronary Arteritis in Acute Kawasaki Disease and Murine Systemic Vasculitis Induced by Candida Albicans Cell Wall Polysaccharide. In: Saji, B., Newburger, J., Burns, J., Takahashi, M. (eds) Kawasaki Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56039-5_2

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  • DOI: https://doi.org/10.1007/978-4-431-56039-5_2

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-56037-1

  • Online ISBN: 978-4-431-56039-5

  • eBook Packages: MedicineMedicine (R0)

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