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The History of Kawasaki Disease: A Personal Perspective

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Abstract

To understand the history of Kawasaki Disease (KD) one has to examine three periods of time: (A) the period from 1960 through the mid-1980s, (B) back to the 1870s, and (C) forward to the present. Dr. Kawasaki’s seminal paper, published in the Japanese-language journal Arerugi (Japanese Journal of Allergy) (Kawasaki, Arerugi [Japanese J Allergy] 16:178–222, 1967) in 1967, is the best starting point, because of its remarkably complete delineation of the clinical features of KD in living children, which is the basis for the diagnostic criteria we use today. The more than 100 years of pathologic records from the first description of fatal KD, by Samuel Gee in 1871, (Gee, St Barth Hosp Rep 7:148, 1871) to Kawasaki’s report includes the era of growing interest in and elegant description of the autopsy diagnosis that came to be called “infantile periarteritis nodosa”. (Munro-Faure, Pediatrics 23:914–926, 1959; Roberts and Fetterman, J Pediatr 63:519–529, 1963) The most recent period, from the mid-1980s to the present, marks the period of international cooperation, heightened interest, and scientific progress in the understanding of this still enigmatic disease. The following chapters will outline the many areas of scientific progress. The history of KD is very personal to me as I have had the special privilege to be a participant in all these eras of discovery.

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References

  1. Kawasaki T. Pediatric acute febrile mucocutaneous lymph node syndrome: clinical observation of 50 cases. Arerugi [Japanese J Allergy]. 1967;16:178–222. PMID:6062087.

    CAS  Google Scholar 

  2. Gee S. Aneurysms of coronary arteries in a boy. St Barth Hosp Rep. 1871;7:148.

    Google Scholar 

  3. Munro-Faure H. Necrotizing arteritis of the coronary vessels in infancy; case report and review of the literature. Pediatrics. 1959;23(5):914–26. PMID:13645127.

    CAS  PubMed  Google Scholar 

  4. Roberts FB, Fetterman GH. Polyarteritis nodosa in infancy. J Pediatr. 1963;63(4):519–29. http://dx.doi.org/10.1016/S0022-3476(63)80361-3 PMID:14074409.

    Article  CAS  PubMed  Google Scholar 

  5. Kawasaki T. Personal communication. May 4, 1974.

    Google Scholar 

  6. Melish ME, Hicks RM, Larson EJ. Mucocutaneous lymph node syndrome in the United States. Am J Dis Child. 1976;130(6):599–607. PMID:7134.

    CAS  PubMed  Google Scholar 

  7. Burns JC, Kushner HI, Bastian JF, Shike H, Shimizu C, Matsubara T, et al. Kawasaki disease: A brief history. Pediatrics. 2000;106(2), E27. http://dx.doi.org/10.1542/peds.106.2.e27 PMID:10920183.

    Article  CAS  PubMed  Google Scholar 

  8. Yamamoto T, Kimura J. Acute febrile mucocutaneous, lymph node Syndrome (Kawasaki) subtype of mucocutaneous ocular syndrome of erythema multiforme complicated with carditis. Shonka Rinsho [Japanese J Pediatr]. 1968;21:336–9.

    Google Scholar 

  9. Shigematsu I. Epidemiology of mucocutaneous lymph node syndrome MCLS. Nippon Shonika Gakkai Zasshi [Acta Pediatr Jpn]. 1972;76:695–6.

    Google Scholar 

  10. Kawasaki T, Naoe S. History of Kawasaki disease. Clin Exp Nephrol. 2014;18(2):301–4. http://dx.doi.org/10.1007/s10157-013-0877-6 PMID:24595558.

    Article  PubMed  Google Scholar 

  11. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974;54(3):271–6. PMID:4153258.

    CAS  PubMed  Google Scholar 

  12. Kato H, Koike S, Yamamoto M, Ito Y, Yano E. Coronary aneurysms in infants and young children with acute febrile mucocutaneous lymph node syndrome. J Pediatr. 1975;86(6):892–8. http://dx.doi.org/10.1016/S0022-3476(75)80220-4 PMID:236368.

    Article  CAS  PubMed  Google Scholar 

  13. Yanagawa H, Ohgane H, Nagai M. Space-time clustering of Kawasaki disease—with special reference to the 1979 and 1982 incidences. Nihon Rinsho. 1983;41(9):1987–93. PMID:6663736.

    CAS  PubMed  Google Scholar 

  14. Furusho K, Kamiya T, Nakano H, Kiyosawa N, Shinomiya K, Hayashidera T, et al. High-dose intravenous gammaglobulin for Kawasaki disease. Lancet. 1984;2(8411):1055–8. http://dx.doi.org/10.1016/S0140-6736(84)91504-6 PMID:6209513.

    Article  CAS  PubMed  Google Scholar 

  15. Landing BH, Larson EJ. Are infantile periarteritis nodosa with coronary artery involvement and fatal mucocutaneous lymph node syndrome the same? Comparison of 20 patients from North America with patients from Hawaii and Japan. Pediatrics. 1977;59(5):651–62. PMID:16242.

    CAS  PubMed  Google Scholar 

  16. Takahashi M, Schieber RA, Wishner SH, Ritchie GW, Francis PS. Selective coronary arteriography in infants and children. Circulation. 1983;68(5):1021–8. http://dx.doi.org/10.1161/01.CIR.68.5.1021 PMID:6616785.

    Article  CAS  PubMed  Google Scholar 

  17. Chung KJ, Brandt L, Fulton DR, Kreidberg MB. Cardiac and coronary arterial involvement in infants and children from New England with mucocutaneous lymph node syndrome (Kawasaki disease). Angiocardiographic-echocardiographic correlations. Am J Cardiol. 1982;50(1):136–42. http://dx.doi.org/10.1016/0002-9149(82)90019-4 PMID:7090996.

    Article  CAS  PubMed  Google Scholar 

  18. Patriarca PA, Rogers MF, Morens DM, Schonberger LB, Kaminski RM, Burns JC, et al. Kawasaki syndrome: association with the application of rug shampoo. Lancet. 1982;2(8298):578–80. http://dx.doi.org/10.1016/S0140-6736(82)90660-2 PMID:6125730.

    Article  CAS  PubMed  Google Scholar 

  19. Dean AG, Melish ME, Hicks R, Palumbo NE. An epidemic of Kawasaki syndrome in Hawaii. J Pediatr. 1982;100(4):552–7. http://dx.doi.org/10.1016/S0022-3476(82)80751-8 PMID:7062202.

    Article  CAS  PubMed  Google Scholar 

  20. Shulman ST, McAuley JB, Pachman LM, Miller ML, Ruschhaupt DG. Risk of coronary abnormalities due to Kawasaki disease in urban area with small Asian population. Am J Dis Child. 1987;141(4):420–5. PMID:3565328.

    CAS  PubMed  Google Scholar 

  21. Rose V, Lightfoot NE, Fournier A, Gibbons JE. The descriptive epidemiology of Kawasaki syndrome in Canada, 1979–1985. Prog Clin Biol Res. 1987;250:45–53. PMID:3423054.

    CAS  PubMed  Google Scholar 

  22. Kushner HI, Bastian JF, Turner CL, Burns JC. The two emergences of Kawasaki syndrome and the implications for the developing world. Pediatr Infect Dis J. 2008;27(5):377–83.

    Article  PubMed  Google Scholar 

  23. Takahashi K, Oharaseki T, Yokouchi Y, Yamada H, Shibuya K, Naoe S. A half-century of autopsy results—incidence of pediatric vasculitis syndromes, especially Kawasaki disease. Circ J. 2012;76(4):964–70. http://dx.doi.org/10.1253/circj.CJ-11-0928 PMID:22313802.

    Article  PubMed  Google Scholar 

  24. Shibuya N, Shibuya K, Kato H, Yanagisawa M. Kawasaki disease before kawasaki at Tokyo university hospital. Pediatrics. 2002;110(2 Pt 1):e17. http://dx.doi.org/10.1542/peds.110.2.e17 PMID:12165616.

    Article  PubMed  Google Scholar 

  25. Kato H, Inoue O, Kawasaki T, Fujiwara H, Watanabe T, Toshima H. Adult coronary artery disease probably due to childhood Kawasaki disease. Lancet. 1992;340(8828):1127–9. http://dx.doi.org/10.1016/0140-6736(92)93152-D PMID:1359212.

    Article  CAS  PubMed  Google Scholar 

  26. Burns JC, Kushner HI, Bastian JF, Shike H, Shimizu C, Matsubara T, Turner CL. Kawasaki disease: a brief history. Pediatrics. 2000;106:e27.

    Article  CAS  PubMed  Google Scholar 

  27. Newburger JW, Takahashi M, Burns JC, Beiser AS, Chung KJ, Duffy CE, et al. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med. 1986;315(6):341–7. http://dx.doi.org/10.1056/NEJM198608073150601 PMID:2426590.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Marian E. Melish .

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Melish, M.E. (2017). The History of Kawasaki Disease: A Personal Perspective. In: Saji, B., Newburger, J., Burns, J., Takahashi, M. (eds) Kawasaki Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56039-5_1

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  • DOI: https://doi.org/10.1007/978-4-431-56039-5_1

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