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Regulation of Cadherin–Catenin Biology by Mechanical Force and Phosphorylation

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The Cadherin Superfamily

Abstract

In the adherens junction (AJ), cadherin and catenin proteins form a cell–cell adhesion complex that is indispensable for tissue morphogenesis and homeostasis. The complex mechanically couples neighboring cells through intercellular binding by cadherins, and actin binding and regulation by the cytoplasmic catenins. In addition, the cadherin–catenin complex participates in signaling pathways that direct cellular organization, proliferation, and motility. Some of these signaling pathways can be regulated by mechanical stimulation or posttranslational modification of the components of the AJ. In light of these findings, we discuss our current understanding of how AJ signaling and mechanical functions are regulated by phosphorylation and force, and speculate on the mechanisms underlying the coordination between these two types of modifications.

J. Tan and B.W. Benham-Pyle contributed equally with all other contributors.

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Acknowledgments

This work was supported by Predoctoral Fellowships from the NSF (JT, BB-P), a Stanford Bio-X Pre-doctoral Fellowship (JT), NSF EFRI Award (1136790) to WJN and WIW, and NIH GM35527 (WJN).

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    Authors and Affiliations

    1. Biophysics Program, Stanford University, Stanford, CA, 94305, USA

      Jiongyi Tan & William I. Weis

    2. Cancer Biology Program, Stanford University, Stanford, CA, 94305, USA

      Blair W. Benham-Pyle, William I. Weis & W. James Nelson

    3. Department of Structural Biology, Stanford University, Stanford, CA, 94305, USA

      William I. Weis

    4. Department of Molecular and Cell Physiology, Stanford University, Stanford, CA, 94305, USA

      William I. Weis & W. James Nelson

    5. Department of Biology, Stanford University, Stanford, CA, 94305, USA

      W. James Nelson

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    1. Jiongyi Tan
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    Correspondence to W. James Nelson .

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    1. Department of Bioscience, Kwansei Gakuin University, Sanda, Hyogo, Japan

      Shintaro T. Suzuki

    2. Department of Cell Biology, Kansai Medical University, Hirakata, Osaka, Japan

      Shinji Hirano

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    Tan, J., Benham-Pyle, B.W., Weis, W.I., Nelson, W.J. (2016). Regulation of Cadherin–Catenin Biology by Mechanical Force and Phosphorylation. In: Suzuki, S., Hirano, S. (eds) The Cadherin Superfamily. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56033-3_5

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