Abstract
In this chapter, two subfamilies of atypical cadherins are described: the subfamily of seven-pass transmembrane cadherins (7-TM cadherins) and Fat and Dachsous cadherins. Pioneering genetic studies in Drosophila have defined both subfamilies and dissected their roles in animal development. It is now clear that the founding members in Drosophila and their respective vertebrate homologues make critical and essential contributions to a variety of dynamic behaviors of cell populations, and that malfunctions of those atypical cadherins cause anomalies in embryonic development, resulting in postnatal organ malformation or embryonic demise. Here we discuss how the atypical cadherins control cell behaviors with the emphasis on one particular orchestration of cells along the axes of tissues, organs, or bodies, inclusively designated as planar cell polarity (PCP). Nowadays the purview of PCP ranges from the unidirectional orientation of subcellular structures, such as wing hairs of Drosophila and vertebrate motile cilia, to three-dimensional dynamics of multicellular units, such as tilting hair follicles, neural tube closure, epithelial folding in the oviduct, and collective cell migration. The PCP field is at an extraordinarily exciting juncture, bursting with questions about functions of 7-TM cadherins and Fat and Dachsous cadherins at the cellular and molecular level.
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Abley K, De Reuille PB, Strutt D et al (2013) An intracellular partitioning-based framework for tissue cell polarity in plants and animals. Development 140:2061–2074. doi:10.1242/dev.062984
Adler PN (2012) The frizzled/stan pathway and planar cell polarity in the Drosophila wing. Curr Top Dev Biol 101:1–31. doi:10.1016/B978-0-12-394592-1.00001-6
Agduhr E (1927) Studies on the structure and development of the bursa ovarica and the tuba uterina in the mouse. Acta Zool 8:1–133. doi:10.1111/j.1463-6395.1927.tb00649.x
Aigouy B, Farhadifar R, Staple DB et al (2010) Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila. Cell 142:773–786. doi:10.1016/j.cell.2010.07.042
Allache R, De Marco P, Merello E et al (2012) Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis. Birth Defects Res A Clin Mol Teratol 94:176–181. doi:10.1002/bdra.23002
Assheton R (1896) Notes on the ciliation of the ectoderm of the amphibian embryo.
Ayukawa T, Akiyama M, Mummery-Widmer JL et al (2014) Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep 8:610–621. doi:10.1016/j.celrep.2014.06.009
Badouel C, Zander M, Liscio N et al (2015) Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Development 142:2781–2791. doi:10.1242/dev.123539
Bagherie-Lachidan M, Reginensi A, Zaveri HP et al (2015) Stromal Fat4 acts non-autonomously with Dachsous1/2 to restrict the nephron progenitor pool. Development 142:2564–2573. doi:10.1242/dev.122648
Bastock R, Strutt H, Strutt D (2003) Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning. Development 130:3007–3014
Bischoff M (2012) Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila. Dev Biol 363:179–190. doi:10.1016/j.ydbio.2011.12.033
Boisvieuxulrich E, Laine MC, Sandoz D (1985) The orientation of ciliary basal bodies in quail oviduct is related to the ciliary beating cycle commencement. Biol Cell 55:147–150
Bosveld F, Bonnet I, Guirao B et al (2012) Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway. Science 336:724–727. doi:10.1126/science.1221071
Boutin C, Labedan P, Dimidschstein J et al (2014) A dual role for planar cell polarity genes in ciliated cells. Proc Natl Acad Sci U S A 111:E3129–E3138. doi:10.1073/pnas.1404988111
Brittle AL, Repiso A, Casal J et al (2010) Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat. Curr Biol 20:803–810. doi:10.1016/j.cub.2010.03.056
Brooks ER, Wallingford JB (2014) Multiciliated cells. Curr Biol 24:R973–R982. doi:10.1016/j.cub.2014.08.047
Butler MT, Wallingford JB (2015) Control of vertebrate core PCP protein localization and dynamics by Prickle2. Development. doi:10.1242/dev.121384
Carvajal-Gonzalez JM, Mlodzik M (2014) Mechanisms of planar cell polarity establishment in Drosophila. F1000Prime Rep 6:98. doi: 10.12703/P6-98
Chae J, Kim MJ, Goo JH et al (1999) The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family. Development 126:5421–5429
Chen W-S, Antic D, Matis M et al (2008) Asymmetric Homotypic Interactions of the Atypical Cadherin Flamingo Mediate Intercellular Polarity Signaling. Cell 133:1093–1105. doi:10.1016/j.cell.2008.04.048
Cho E, Irvine KD (2004) Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling. Development 131:4489–4500. doi:10.1242/dev.01315
Clark HF, Brentrup D, Schneitz K et al (1995) Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev 9:1530–1542. doi:10.1101/gad.9.12.1530
Classen AK, Anderson KI, Marois E, Eaton S (2005) Hexagonal packing of Drosophila wing epithelial cells by the planar cell polarity pathway. Dev Cell 9:805–817. doi:10.1016/j.devcel.2005.10.016
Cortijo C, Gouzi M, Tissir F, Grapin-Botton A (2012) Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep 2:1593–1606. doi:10.1016/j.celrep.2012.10.016
Curtin JA, Quint E, Tsipouri V et al (2003) Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol 13:1129–1133. doi:10.1016/s0960-9822(03)00374-9
Davies A, Formstone C, Mason I, Lewis J (2005) Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-flamingo-1 protein. Dev Dyn 233:998–1005. doi:10.1002/dvdy.20376
Del Bigio MR (1995) The ependyma: a protective barrier between brain and cerebrospinal fluid. Glia 14:1–13. doi:10.1002/glia.440140102
Devenport D (2014) Cell biology in development: The cell biology of planar cell polarity. J Cell Biol 207:171–179. doi:10.1083/jcb.201408039
Devenport D, Fuchs E (2008) Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol 10:1257–1268. doi:10.1038/ncb1784
Devenport D, Oristian D, Heller E, Fuchs E (2011) Mitotic internalization of planar cell polarity proteins preserves tissue polarity. Nat Cell Biol 13:893–902. doi:10.1038/ncb2284
Doudney K, Stanier P (2005) Epithelial cell polarity genes are required for neural tube closure. Am J Med Genet C: Semin Med Genet 135C:42–47. doi:10.1002/ajmg.c.30052
Durst R, Sauls K, Peal DS et al (2015) Mutations in DCHS1 cause mitral valve prolapse. Nature. doi:10.1038/nature14670
Feng Y, Irvine KD (2009) Processing and phosphorylation of the Fat receptor. Proc Natl Acad Sci U S A 106:11989–11994. doi:10.1073/pnas.0811540106
Fuchs E (2007) Scratching the surface of skin development. Nature 445:834–842. doi:10.1038/nature05659
Gaengel K, Mlodzik M (2003) Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. Development 130:5413–5423. doi:10.1242/dev.00759
Gong Y, Mo C, Fraser SE (2004) Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature 430:689–693. doi:10.1038/nature02796
Goodrich LV, Strutt D (2011) Principles of planar polarity in animal development. Development 138:1877–1892. doi:10.1242/dev.054080
Gray RS, Roszko I, Solnica-Krezel L (2011) Planar cell polarity: coordinating morphogenetic cell behaviors with embryonic polarity. Dev Cell 21:120–133. doi:10.1016/j.devcel.2011.06.011
Guirao B, Meunier A, Mortaud S et al (2010) Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat Cell Biol 12:341–350. doi:10.1038/ncb2040
Hadjantonakis AK, Sheward WJ, Harmar AJ et al (1997) Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics 45:97–104. doi:10.1006/geno.1997.4892
Hakeda-Suzuki S, Berger-Müller S, Tomasi T et al (2011) Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system. Nat Neurosci 14:314–323. doi:10.1038/nn.2756
Hale R, Brittle AL, Fisher KH et al (2015) Cellular interpretation of the long-range gradient of Four-jointed activity in the Drosophila wing. Elife. doi:10.7554/eLife.05789
Harumoto T, Ito M, Shimada Y et al (2010) Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity. Dev Cell 19:389–401. doi:10.1016/j.devcel.2010.08.004
Heisenberg CP, Bellaïche Y (2013) Forces in Tissue Morphogenesis and Patterning. Cell 153:948–962. doi:10.1016/j.cell.2013.05.008
Hirano S, Takeichi M (2012) Cadherins in brain morphogenesis and wiring. Physiol Rev 92:597–634. doi:10.1152/physrev.00014.2011
Hirota Y, Meunier A, Huang S et al (2010) Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II. Development 137:3037–3046. doi:10.1242/dev.050120
Hoeng JC, Höng JC, Ivanov NV et al (2004) Identification of new human cadherin genes using a combination of protein motif search and gene finding methods. J Mol Biol 337:307–317. doi:10.1016/j.jmb.2004.01.026
Ishikawa HO, Takeuchi H, Haltiwanger RS, Irvine KD (2008) Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains. Science 321:401–404. doi:10.1126/science.1158159
Ishiuchi T, Misaki K, Yonemura S et al (2009) Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. J Cell Biol 185:959–967. doi:10.1083/jcb.200811030
Jolly MK, Rizvi MS, Kumar A, Sinha P (2014) Mathematical modeling of sub-cellular asymmetry of fat-dachsous heterodimer for generation of planar cell polarity. PLoS One 9:e97641. doi:10.1371/journal.pone.0097641
Juriloff DM, Harris MJ (2012) A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects. Birth Defects Res A Clin Mol Teratol 94:824–840. doi:10.1002/bdra.23079
Lawrence PA, Casal J (2013) The mechanisms of planar cell polarity, growth and the Hippo pathway: some known unknowns. Dev Biol 377:1–8. doi:10.1016/j.ydbio.2013.01.030
Li-Villarreal N, Forbes MM, Loza AJ et al (2015) Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development 142:2704–2718. doi:10.1242/dev.119800
Lu B, Usui T, Uemura T et al (1999) Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila. Curr Biol 9:1247–1250. doi:10.1016/S0960-9822(99)80505-3
Lu Q, Schafer DA, Adler PN (2015) The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton. Development 142:2478–2486. doi:10.1242/dev.122119
Lucas AM, Douglas LC (1934) Principles underlying ciliary activity in the respiratory tract: II. A comparison of nasal clearance in man, monkey and other mammals. Arch Otolaryngol Head Neck Surg 20:518–541. doi:10.1001/archotol.1934.03600040074006
Ma D, Yang C, McNeill H et al (2003) Fidelity in planar cell polarity signalling. Nature 421:543–547. doi:10.1038/nature01366
Mahoney PA, Weber U, Onofrechuk P et al (1991) The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67:853–868. doi:10.1016/0092-8674(91)90359-7
Mani M, Goyal S, Irvine KD, Shraiman BI (2013) Collective polarization model for gradient sensing via Dachsous-Fat intercellular signaling. Proc Natl Acad Sci U S A 110:20420–20425. doi:10.1073/pnas.1307459110
Mao Y, Mulvaney J, Zakaria S et al (2011) Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development 138:947–957. doi:10.1242/dev.057166
Mao Y, Francis-West P, Irvine KD (2015) A Fat4-Dchs1 signal between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development 142:2574–2585. doi:10.1242/dev.122630
Matakatsu H, Blair SS (2004) Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development 131:3785–3794. doi:10.1242/dev.01254
Matis M, Axelrod JD (2013) Regulation of PCP by the Fat signaling pathway. Genes Dev 27:2207–2220. doi:10.1101/gad.228098.113
Matis M, Russler-Germain DA, Hu Q et al (2014) Microtubules provide directional information for core PCP function. Elife 3:e02893. doi:10.7554/eLife.02893
Matsubara D, Horiuchi S-Y, Shimono K et al (2011) The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. Genes Dev 25:1982–1996. doi:10.1101/gad.16531611
May-Simera H, Kelley MW (2012) Planar cell polarity in the inner ear. Curr Top Dev Biol 101:111–140. doi:10.1016/B978-0-12-394592-1.00006-5
Merkel M, Sagner A, Gruber FS et al (2014) The balance of prickle/spiny-legs isoforms controls the amount of coupling between core and fat PCP systems. Curr Biol 24:2111–2123. doi:10.1016/j.cub.2014.08.005
Mirzadeh Z, Han Y-G, Soriano-Navarro M et al (2010) Cilia organize ependymal planar polarity. J Neurosci 30:2600–2610. doi:10.1523/JNEUROSCI.3744-09.2010
Nakajima D, Nakayama M, Kikuno R et al (2001) Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs. Mol Brain Res 94:85–95. doi:10.1016/S0169-328X(01)00218-2
Nakayama M, Nakajima D, Nagase T et al (1998) Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. Genomics 51:27–34. doi:10.1006/geno.1998.5341
Nishimura T (2014) Making the Neural Plate to Fold into a Tube. In: Kondoh H, Kuroiwa A (eds) New Principles in Developmental Processes. Springer Japan, Tokyo, pp 123–136
Nishimura T, Honda H, Takeichi M (2012) Planar cell polarity links axes of spatial dynamics in neural-tube closure. Cell 149:1084–1097. doi:10.1016/j.cell.2012.04.021
Olofsson J, Sharp KA, Matis M et al (2014) Prickle/spiny-legs isoforms control the polarity of the apical microtubule network in planar cell polarity. Development 141:2866–2874. doi:10.1242/dev.105932
Qu Y, Glasco DM, Zhou L et al (2010) Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci 30:9392–9401. doi:10.1523/JNEUROSCI.0124-10.2010
Ravni A, Qu Y, Goffinet AM, Tissir F (2009) Planar cell polarity cadherin Celsr1 regulates skin hair patterning in the mouse. J Invest Dermatol 129:2507–2509. doi:10.1038/jid.2009.84
Robinson A, Escuin S, Doudney K et al (2012) Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis. Hum Mutat 33:440–447. doi:10.1002/humu.21662
Rock R, Schrauth S, Gessler M (2005) Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Dev Dyn 234:747–755. doi:10.1002/dvdy.20515
Saburi S, Hester I, Fischer E et al (2008) Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nat Genet 40:1010–1015. doi:10.1038/ng.179
Saburi S, Hester I, Goodrich L, McNeill H (2012) Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. Development 139:1806–1820. doi:10.1242/dev.077461
Sadeqzadeh E, de Bock CE, Thorne RF (2014) Sleeping giants: emerging roles for the fat cadherins in health and disease. Med Res Rev 34:190–221. doi:10.1002/med.21286
Sagner A, Merkel M, Aigouy B et al (2012) Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium. Curr Biol 22:1296–1301. doi:10.1016/j.cub.2012.04.066
Sai X, Yonemura S, Ladher RK (2014) Junctionally restricted RhoA activity is necessary for apical constriction during phase 2 inner ear placode invagination. Dev Biol 394:206–216. doi:10.1016/j.ydbio.2014.08.022
Schwabe T, Neuert H, Clandinin TR (2013) A network of cadherin-mediated interactions polarizes growth cones to determine targeting specificity. Cell 154:351–364. doi:10.1016/j.cell.2013.06.011
Sharma P, McNeill H (2013) Regulation of long-range planar cell polarity by Fat-Dachsous signaling. Development 140:3869–3881. doi:10.1242/dev.094730
Shi D, Fujimori T, Uemura T (2013) Atypical cadherin negotiates a turn. Dev Cell 26:1–2
Shi D, Komatsu K, Hirao M et al (2014) Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct. Development 141:4558–4568. doi:10.1242/dev.115659
Shima Y, Kawaguchi S, Kosaka K et al (2007) Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Nat Neurosci 10:963–969. doi:10.1038/nn1933
Shimada Y, Yonemura S, Ohkura H et al (2006) Polarized transport of Frizzled along the planar microtubule arrays in Drosophila wing epithelium. Dev Cell 10:209–222. doi:10.1016/j.devcel.2005.11.016
Shrestha R, Little KA, Tamayo JV et al (2015) Mitotic Control of Planar Cell Polarity by Polo-like Kinase 1. Dev Cell 33:522–534. doi:10.1016/j.devcel.2015.03.024
Simon MA, Xu A, Ishikawa HO, Irvine KD (2010) Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed. Curr Biol 20:811–817. doi:10.1016/j.cub.2010.04.016
Sopko R, Silva E, Clayton L et al (2009) Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown. Curr Biol 19:1112–1117. doi:10.1016/j.cub.2009.05.049
St Johnston D, Sanson B (2011) Epithelial polarity and morphogenesis. Curr Opin Cell Biol 23:540–546. doi:10.1016/j.ceb.2011.07.005
Striedter GF, Srinivasan S, Monuki ES (2015) Cortical folding: when, where, how, and why? Annu Rev Neurosci 38:291–307. doi:10.1146/annurev-neuro-071714-034128
Strutt DI (2001) Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. Mol Cell 7:367–375
Strutt H, Strutt D (2002) Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled. Dev Cell 3:851–863
Strutt H, Strutt D (2008) Differential stability of flamingo protein complexes underlies the establishment of planar polarity. Curr Biol 18:1555–1564. doi:10.1016/j.cub.2008.08.063
Sugimura K, Ishihara S (2013) The mechanical anisotropy in a tissue promotes ordering in hexagonal cell packing. Development 140:4091–4101. doi:10.1242/dev.094060
Sugimura R, He XC, Venkatraman A et al (2012) Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell 150:351–365. doi:10.1016/j.cell.2012.05.041
Sulik K, Dehart DB, Iangaki T et al (1994) Morphogenesis of the murine node and notochordal plate. Dev Dyn 201:260–278. doi:10.1002/aja.1002010309
Tada M, Heisenberg C-P (2012) Convergent extension: using collective cell migration and cell intercalation to shape embryos. Development 139:3897–3904. doi:10.1242/dev.073007
Tada M, Kai M (2012) Planar cell polarity in coordinated and directed movements. Curr Top Dev Biol 101:77–110. doi:10.1016/B978-0-12-394592-1.00004-1
Takeichi M (2007) The cadherin superfamily in neuronal connections and interactions. Nat Rev Neurosci 8:11–20. doi:10.1038/nrn2043
Tanoue T, Takeichi M (2004) Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol 165:517–528. doi:10.1083/jcb.200403006
Tatin F, Taddei A, Weston A et al (2013) Planar cell polarity protein celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. Dev Cell 26:31–44. doi:10.1016/j.devcel.2013.05.015
Taylor J, Abramova N, Charlton J, Adler PN (1998) Van Gogh: a new Drosophila tissue polarity gene. Genetics 150:199–210
Thomas C, Strutt D (2012) The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila. Dev Dyn 241:27–39. doi:10.1002/dvdy.22736
Tissir F, Goffinet AM (2013) Shaping the nervous system: role of the core planar cell polarity genes. Nat Rev Neurosci 14:525–535. doi:10.1038/nrn3525
Tissir F, Qu Y, Montcouquiol M et al (2010) Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus. Nat Neurosci 13:700–707. doi:10.1038/nn.2555
Tsukasaki Y, Miyazaki N, Matsumoto A et al (2014) Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions. Proc Natl Acad Sci U S A 111:16011–16016. doi:10.1073/pnas.1418990111
Usui T, Shima Y, Shimada Y et al (1999) Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of frizzled. Cell 98:585–595. doi:10.1016/S0092-8674(00)80046-X
Vichas A, Zallen JA (2011) Translating cell polarity into tissue elongation. Semin Cell Dev Biol 22:858–864. doi:10.1016/j.semcdb.2011.09.013
Villano J, Katz F (1995) four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila. Development 121:2767–2777
Vladar EK, Antic D, Axelrod JD (2009) Planar cell polarity signaling: the developing cell’s compass. Cold Spring Harb Perspect Biol 1:a002964. doi:10.1101/cshperspect.a002964
Vladar EK, Bayly RD, Sangoram AM et al (2012) Microtubules enable the planar cell polarity of airway cilia. Curr Biol 22:2203–2212. doi:10.1016/j.cub.2012.09.046
Vladar EK, Lee YL, Stearns T, Axelrod JD (2015) Observing planar cell polarity in multiciliated mouse airway epithelial cells. Methods Cell Biol 127:37–54. doi:10.1016/bs.mcb.2015.01.016
Wada H, Okamoto H (2009) Roles of planar cell polarity pathway genes for neural migration and differentiation. Dev Growth Differ 51:233–240. doi:10.1111/j.1440-169X.2009.01092.x
Wada H, Tanaka H, Nakayama S et al (2006) Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrain. Development 133:4749–4759. doi:10.1242/dev.02665
Wallingford JB (2012) Planar cell polarity and the developmental control of cell behavior in vertebrate embryos. Annu Rev Cell Dev Biol 28:627–653. doi:10.1146/annurev-cellbio-092910-154208
Wallingford JB, Niswander LA, Shaw GM, Finnell RH (2013) The continuing challenge of understanding, preventing, and treating neural tube defects. Science 339:1222002. doi:10.1126/science.1222002
Wang X-J, Zhang D-L, Xu Z-G et al (2014a) Understanding cadherin EGF LAG seven-pass G-type receptors. J Neurochem 131:699–711. doi:10.1111/jnc.12955
Wang Y, Yan J, Lee H et al (2014b) The proteins encoded by the Drosophila Planar Polarity Effector genes inturned, fuzzy and fritz interact physically and can re-pattern the accumulation of “upstream” Planar Cell Polarity proteins. Dev Biol 394:156–169. doi:10.1016/j.ydbio.2014.07.013
Wolff T, Rubin GM (1998) Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila. Development 125:1149–1159
Wong LL, Adler PN (1993) Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells. J Cell Biol 123:209–221
Wu J, Roman A-C, Carvajal-Gonzalez JM, Mlodzik M (2013) Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila. Nat Cell Biol 15:1045–1055. doi:10.1038/ncb2806
Yamaguchi Y, Miura M (2013) How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals. Cell Mol Life Sci 70:3171–3186. doi:10.1007/s00018-012-1227-7
Yang Y (ed) (2012) Planar cell polarity during development, 1st edn. Academic, USA
Yang C, Axelrod JD, Simon MA (2002) Regulation of Frizzled by Fat-like Cadherins during Planar Polarity Signaling in the Drosophila Compound Eye. Cell 108:675–688. doi:10.1016/S0092-8674(02)00658-X
Zakaria S, Mao Y, Kuta A et al (2014) Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity. Curr Biol 24:1620–1627. doi:10.1016/j.cub.2014.05.067
Zecca M, Struhl G (2010) A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol 8:e1000386. doi:10.1371/journal.pbio.1000386
Zeidler MP, Perrimon N, Strutt DI (2000) Multiple roles for four-jointed in planar polarity and limb patterning. Dev Biol 228:181–196. doi:10.1006/dbio.2000.9940
Acknowledgments
This work was supported by a CREST grant and MEXT grands (Kakenhi) to T.U. and T.F,, and by a grant of The Mitsubishi Foundation and Takeda Science Foundation to T.U and a grant from NIBB to T.F. D.S. and M. A. were Research Fellows of the JSPS. Figure 10.4e is reprinted from “Flamingo, a Seven-Pass Transmembrane Cadherin, Regulates Planar Cell Polarity under the Control of Frizzled” by Usui et al., Cell, Volume 98, 585–595, 1999, with permission from Elsevier. We thank J. A. Hejna very much for his constructive suggestions and polishing the manuscript.
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Shi, D., Arata, M., Usui, T., Fujimori, T., Uemura, T. (2016). Seven-Pass Transmembrane Cadherin CELSRs, and Fat4 and Dchs1 Cadherins: From Planar Cell Polarity to Three-Dimensional Organ Architecture. In: Suzuki, S., Hirano, S. (eds) The Cadherin Superfamily. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56033-3_10
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DOI: https://doi.org/10.1007/978-4-431-56033-3_10
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Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-56031-9
Online ISBN: 978-4-431-56033-3
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