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Inflammation and Metastasis pp 145–161Cite as

Autoinflammatory Disorders

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Abstract

We have discussed the actual presence of the endogenous ligands for TLR. In this chapter, I will describe their potential involvement in human diseases. Given that metastasis is a clinical name or name of a disease, I believe that any research irrelevant to or in disagreement to clinical information is of low value. There is no doubt that fever is one of the fundamental symptoms of ambiguously defined “inflammatory disorders” in clinical settings. For example, if clinical manifestations of a patient involve fever of unknown origin (FUO), being febrile >38.3 °C for more than 3 weeks with failure to reach diagnosis, medical doctors usually think of (1) infectious, (2) neoplastic, and (3) noninfectious inflammatory diseases [1]. The third group mainly includes autoimmune disorders, such as systemic lupus erythematosus (SLE) (see Chap. 4), which affect connective tissues. Patients with autoimmune disorders almost always have autoantibodies, pathologically directed against their own cells or tissue components as seen with Guillain-Barré syndrome (see Chap. 4). However, their etiology is not well defined.

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Authors and Affiliations

  1. Department of Pharmacology, Tokyo Women’s Medical University, Tokyo, Japan

    Yoshiro Maru

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Maru, Y. (2016). Autoinflammatory Disorders. In: Inflammation and Metastasis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56024-1_8

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